Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 596 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 585 | - |
dc.citation.title | KOREAN JOURNAL OF RADIOLOGY | - |
dc.citation.volume | 18 | - |
dc.contributor.author | Park, Bum Woo | - |
dc.contributor.author | Choi, Byung Se | - |
dc.contributor.author | Sung, Yu Sub | - |
dc.contributor.author | Woo, Dong-Cheol | - |
dc.contributor.author | Shim, Woo Hyun | - |
dc.contributor.author | Kim, Kyung Won | - |
dc.contributor.author | Choi, Soon Seok | - |
dc.contributor.author | Pae, Sang Joon | - |
dc.contributor.author | Suh, Ji-Yeon | - |
dc.contributor.author | Cho, Hyungjoon | - |
dc.contributor.author | Kim, Jeong Kon | - |
dc.date.accessioned | 2023-12-21T22:09:04Z | - |
dc.date.available | 2023-12-21T22:09:04Z | - |
dc.date.created | 2017-03-27 | - |
dc.date.issued | 2017-07 | - |
dc.description.abstract | Objective: To simulate the B1-inhomogeneity-induced variation of pharmacokinetic parameters on DCE-MRI. Materials and Methods: B1-inhomogeneity-induced flip angle (FA) variation was estimated in a phantom study. Monte Carlo simulation was performed to assess the FA-deviation-induced measurement error of the pre-contrast R1, contrast-enhancement ratio, Gd concentration, and two-compartment pharmacokinetic parameters (Ktrans, ve and vp). Results: B1-inhomogeneity resulted in -23% ~ 5% fluctuations (95% confidence interval (CI) of % error) of FA. The 95% CIs of FA-dependent % errors in the gray matter and blood were as follows: -16.7% - 61.8% and -16.7% - 61.8% for the pre-contrast R1, -1.0% - 0.3% and -5.2% - 1.3% for the contrast-enhancement ratio, and -14.2% - 58.1% and -14.1% - 57.8% for the Gd concentration, respectively. These resulted in -43.1% - 48.4% error for Ktrans, -32.3% - 48.6% error for the ve, and -43.2% - 48.6% error for vp. The pre-contrast R1 was more vulnerable to FA error than the contrast-enhancement ratio, and was therefore a significant cause of the Gd-concentration error. For example, a -10% FA error led to a 23.6% deviation in the pre-contrast R1, -0.4% in the contrast-enhancement ratio, and 23.6% in the Gd concentration. In a simulated condition with a 3% FA error in a target lesion and a -10% FA error in a feeding vessel, the % errors of the pharmacokinetic parameters were -23.7% for Ktrans, -23.7% for ve, and -23.7% for vp. Conclusion: Even a small degree of B1-inhomogeneity can cause a significant error in the measurement of pharmacokinetic parameters on DCE-MRI, while the vulnerability of the pre-contrast R1 calculations to FA deviations is a significant cause of the miscalculation. |
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dc.identifier.bibliographicCitation | KOREAN JOURNAL OF RADIOLOGY, v.18, no.4, pp.585 - 596 | - |
dc.identifier.doi | 10.3348/kjr.2017.18.4.585 | - |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.scopusid | 2-s2.0-85020650795 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/21678 | - |
dc.identifier.url | https://synapse.koreamed.org/DOIx.php?id=10.3348/kjr.2017.18.4.585 | - |
dc.identifier.wosid | 000402487000003 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN RADIOLOGICAL SOC | - |
dc.title | Influence of B1 Inhomogeneity on Pharmacokinetic Modeling of Dynamic Contrast-Enhanced MRI: A Simulation Study | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.identifier.kciid | ART002248548 | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Brain | - |
dc.subject.keywordAuthor | Magnetic resonance imaging | - |
dc.subject.keywordAuthor | Dynamic contrast enhancement | - |
dc.subject.keywordAuthor | Monte Carlo method | - |
dc.subject.keywordAuthor | Phantoms, imaging | - |
dc.subject.keywordPlus | DCE-MRI | - |
dc.subject.keywordPlus | FIELD INHOMOGENEITY | - |
dc.subject.keywordPlus | 3.0 T | - |
dc.subject.keywordPlus | BREAST | - |
dc.subject.keywordPlus | PERFUSION | - |
dc.subject.keywordPlus | B-1 | - |
dc.subject.keywordPlus | PARAMETERS | - |
dc.subject.keywordPlus | TRACER | - |
dc.subject.keywordPlus | ERRORS | - |
dc.subject.keywordPlus | 3T | - |
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