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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 390 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 383 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.citation.volume | 35 | - |
dc.contributor.author | Kim, Hak Sun | - |
dc.contributor.author | Park, Won Sang | - |
dc.contributor.author | Baek, Jong-In | - |
dc.contributor.author | Lee, Bo-Sub | - |
dc.contributor.author | Yoo, Dae Sung | - |
dc.contributor.author | Park, Si Jun | - |
dc.date.accessioned | 2023-12-22T01:39:00Z | - |
dc.date.available | 2023-12-22T01:39:00Z | - |
dc.date.created | 2017-03-03 | - |
dc.date.issued | 2015-02 | - |
dc.description.abstract | Accumulating evidence has indicated that the light source emitted from light-emitting diode (LED) has a potential anti-aging effect on human skin. Studies using single and interval LED irradiation have documented such effects; however, to the best of our knowledge, the anti-aging effects of continuous LED irradiation have not yet been investigated. In the present study, we demonstrated that continuous irradiation with a 633 +/- 3-nm LED exerted anti-aging effects in both in vitro and ex vivo experiments. More specifically, irradiation with a 633-nm LED for 2 days increased the synthesis of type 1 procollagen and decreased the expression of matrix metalloproteinase (MMP)1 and MMP2 in skin fibroblasts. In addition, irradiation with a 633-nm LED decreased the expression levels of inflammatory genes, such has cyclooxygenase-2 (COX-2), and interleukin-1-alpha (IL-1 alpha) in keratinocytes. Furthermore, a 14-day LED irradiation moderately increased keratinocyte proliferation. Using human skin explants, we confirmed the safety of this 633-nm LED irradiation, which resulted in unaltered morphology and allergy-free potential in human tissue. Overall, these data provide insight into the anti-aging effects of continuous LED irradiation on human skin. | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, v.35, no.2, pp.383 - 390 | - |
dc.identifier.doi | 10.3892/ijmm.2014.2030 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.scopusid | 2-s2.0-84919618900 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/21535 | - |
dc.identifier.url | https://www.spandidos-publications.com/10.3892/ijmm.2014.2030 | - |
dc.identifier.wosid | 000349506700012 | - |
dc.language | 영어 | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.title | Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | light-emitting diode | - |
dc.subject.keywordAuthor | 633 nm wavelength | - |
dc.subject.keywordAuthor | skin | - |
dc.subject.keywordAuthor | anti-aging | - |
dc.subject.keywordAuthor | irradiation | - |
dc.subject.keywordPlus | INTENSE PULSED-LIGHT | - |
dc.subject.keywordPlus | HUMAN KERATINOCYTES | - |
dc.subject.keywordPlus | HUMAN FIBROBLASTS | - |
dc.subject.keywordPlus | MOUSE SKIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | EXTRACT | - |
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