Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 334 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 329 | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 32 | - |
dc.contributor.author | Lee, Sang Don | - |
dc.contributor.author | Chung, Jae Min | - |
dc.contributor.author | Kang, Dong Il | - |
dc.contributor.author | Ryu, Dong Soo | - |
dc.contributor.author | Cho, Won Yeol | - |
dc.contributor.author | Park, Sungchan | - |
dc.date.accessioned | 2023-12-21T22:40:23Z | - |
dc.date.available | 2023-12-21T22:40:23Z | - |
dc.date.created | 2017-02-17 | - |
dc.date.issued | 2017-02 | - |
dc.description.abstract | We investigated the efficacy and tolerability of solifenacin 5 mg fixed dose in children with newly diagnosed idiopathic overactive bladder (OAB). A total of 34 children (male/female patients = 16/18) aged under 13 years (mean age: 7.2 +/- 2.3; range: 5-12) who were newly diagnosed with OAB from January 2012 to September 2014 were prospectively evaluated with open-label protocol. All patients were treated with solifenacin 5 mg fixed dose once daily for at least 4 weeks. The efficacy and tolerability of solifenacin were evaluated 4, 8, and 12 weeks after the initiation of treatment. The mean voiding frequency during daytime was decreased from 9.4 +/- 3.0 to 6.5 +/- 2.3 times after the 12-week treatment (P<0.001). The mean total OAB symptom score (OABSS) decreased from 7.7 +/- 4.2 to 3.1 +/- 3.1 after the 12-week treatment (P<0.001). The urgency and urgency urinary incontinence (UUI) domains significantly improved from the 12-week treatment, and complete resolution of urgency occurred in 38.9% of patients and the percentage of children with UUI among urgent patients decreased from 79.4% to 57.1%. According to 3-day voiding diaries, the average bladder capacity increased from 90.4 +/- 44.4 to 156.2 +/- 67.3 mL (P<0.001). Drug-induced adverse effects (AEs) were reported in 7 patients (20.6%). Our results indicate that solifenacin 5 mg fixed dose is effective against OAB symptoms, and its tolerability is acceptable without significant AEs in children with OAB. | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.32, no.2, pp.329 - 334 | - |
dc.identifier.doi | 10.3346/jkms.2017.32.2.329 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.scopusid | 2-s2.0-85011706670 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/21376 | - |
dc.identifier.url | https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2017.32.2.329 | - |
dc.identifier.wosid | 000392204500023 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Efficacy and Tolerability of Solifenacin 5 mg Fixed Dose in Korean Children with Newly Diagnosed Idiopathic Overactive Bladder: a Multicenter Prospective Study | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Anticholinergics | - |
dc.subject.keywordAuthor | Child | - |
dc.subject.keywordAuthor | Efficacy | - |
dc.subject.keywordAuthor | Overactive Bladder | - |
dc.subject.keywordAuthor | Tolerability | - |
dc.subject.keywordPlus | DETRUSOR OVERACTIVITY | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | PROPIVERINE | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | INCONTINENCE | - |
dc.subject.keywordPlus | FESOTERODINE | - |
dc.subject.keywordPlus | OXYBUTYNIN | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | MIRABEGRON | - |
dc.subject.keywordPlus | SYMPTOMS | - |
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