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Cho, Jaeheung
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dc.citation.endPage 1653 -
dc.citation.number 7 -
dc.citation.startPage 1645 -
dc.citation.volume 23 - Kang, Juhye - Lee, Shin Jung C. - Nam. Jung Seung - Lee, Hyuck Jin - Kang, Mueong-G. - Korshavn, Kyle J. - Kim, Hyun-Tak - Cho, Jaeheung - Ramamoorthy, Ayyalusamy - Rhee, Hyun-Woo - Kwon, Tae-Hyuk - Lim, Mi Hee - 2023-12-21T22:44:25Z - 2023-12-21T22:44:25Z - 2017-01-19 - 2017-01 -
dc.description.abstract Aggregates of amyloidogenic peptides are involved in the pathogenesis of several degenerative disorders. Herein, an iridium(III) complex, Ir-1, is reported as a chemical tool for oxidizing amyloidogenic peptides upon photoactivation and subsequently modulating their aggregation pathways. Ir-1 was rationally designed based on multiple characteristics, including 1)photoproperties leading to excitation by low-energy radiation; 2)generation of reactive oxygen species responsible for peptide oxidation upon photoactivation under mild conditions; and 3)relatively easy incorporation of a ligand on the IrIII center for specific interactions with amyloidogenic peptides. Biochemical and biophysical investigations illuminate that the oxidation of representative amyloidogenic peptides (i.e., amyloid-β, α-synuclein, and human islet amyloid polypeptide) is promoted by light-activated Ir-1, which alters the conformations and aggregation pathways of the peptides. Additionally, their potential oxidation sites are identified as methionine, histidine, or tyrosine residues. Overall, our studies on Ir-1 demonstrate the feasibility of devising metal complexes as chemical tools suitable for elucidating the nature of amyloidogenic peptides at the molecular level, as well as controlling their aggregation. -
dc.identifier.bibliographicCitation CHEMISTRY-A EUROPEAN JOURNAL, v.23, no.7, pp.1645 - 1653 -
dc.identifier.doi 10.1002/chem.201604751 -
dc.identifier.issn 0947-6539 -
dc.identifier.scopusid 2-s2.0-85007552127 -
dc.identifier.uri -
dc.identifier.url -
dc.identifier.wosid 000395754200024 -
dc.language 영어 -
dc.publisher WILEY-V C H VERLAG GMBH -
dc.title An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Chemistry, Multidisciplinary -
dc.relation.journalResearchArea Chemistry -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor aggregation -
dc.subject.keywordAuthor iridium -
dc.subject.keywordAuthor oxidation -
dc.subject.keywordAuthor peptides -
dc.subject.keywordAuthor photochemistry -
dc.subject.keywordPlus METAL-CATALYZED OXIDATION -
dc.subject.keywordPlus MOBILITY-MASS SPECTROMETRY -
dc.subject.keywordPlus ALPHA-SYNUCLEIN -
dc.subject.keywordPlus CROSS-LINKING -
dc.subject.keywordPlus ALZHEIMERS-DISEASE -
dc.subject.keywordPlus BETA-PEPTIDE -
dc.subject.keywordPlus A-BETA -
dc.subject.keywordPlus METHIONINE OXIDATION -
dc.subject.keywordPlus PARKINSONS-DISEASE -


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