There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 323 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 310 | - |
dc.citation.title | CHEMICAL SOCIETY REVIEWS | - |
dc.citation.volume | 46 | - |
dc.contributor.author | Lee, Shin Jung C. | - |
dc.contributor.author | Nam, Eunju | - |
dc.contributor.author | Lee, Hyuck Jin | - |
dc.contributor.author | Savelieff, Masha G. | - |
dc.contributor.author | Lim, Mi Hee | - |
dc.date.accessioned | 2023-12-21T22:44:23Z | - |
dc.date.available | 2023-12-21T22:44:23Z | - |
dc.date.created | 2017-01-24 | - |
dc.date.issued | 2017-01 | - |
dc.description.abstract | Alzheimer's disease (AD) is characterized by an imbalance between production and clearance of amyloid-β (Aβ) species. Aβ peptides can transform structurally from monomers into β-stranded fibrils via multiple oligomeric states. Among the various Aβ species, structured oligomers are proposed to be more toxic than fibrils; however, the identification of Aβ oligomers has been challenging due to their heterogeneous and metastable nature. Multiple techniques have recently helped us gain a better understanding of oligomers' assembly details and structural properties. Moreover, some progress on elucidating the mechanisms of oligomer-triggered toxicity has been made. Based on the collection of current findings, there is growing consensus that control of toxic Aβ oligomers could be a valid approach to regulate Aβ-associated toxicity, which could advance development of new diagnostics and therapeutics for amyloid-related diseases. In this review, we summarize the recent understanding of Aβ oligomers' assembly, structural properties, and toxicity, along with inhibitors against Aβ aggregation, including oligomerization. | - |
dc.identifier.bibliographicCitation | CHEMICAL SOCIETY REVIEWS, v.46, no.2, pp.310 - 323 | - |
dc.identifier.doi | 10.1039/C6CS00731G | - |
dc.identifier.issn | 0306-0012 | - |
dc.identifier.scopusid | 2-s2.0-85010520741 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/21209 | - |
dc.identifier.url | http://pubs.rsc.org/en/content/articlelanding/2017/cs/c6cs00731g#!divAbstract | - |
dc.identifier.wosid | 000394561900001 | - |
dc.language | 영어 | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Towards an understanding of amyloid-beta oligomers: characterization, toxicity mechanisms, and inhibitors | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | PROTEIN OLIGOMERIZATION | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | MOLECULE | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.subject.keywordPlus | A-BETA | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | IN-VIVO | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.