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dc.citation.number 1 -
dc.citation.startPage 100 -
dc.citation.title MOLECULAR BRAIN -
dc.citation.volume 9 - Hong, Joohyeon - Lee, Jungryun - Song, Kiyeong - Ha, Go Eun - Yang, Yong Ryoul - Ma, Ji Su - Yamamoto. Masahiro - Shin, Hee-Sup - Suh, Pann-Ghill - Cheong. Eunji - 2023-12-21T22:49:34Z - 2023-12-21T22:49:34Z - 2017-01-06 - 2016-12 -
dc.description.abstract The transition from wakefulness to a nonrapid eye movement (NREM) sleep state at the onset of sleep involves a transition from low-voltage, high-frequency irregular electroencephalography (EEG) waveforms to large-amplitude, low-frequency EEG waveforms accompanying synchronized oscillatory activity in the thalamocortical circuit. The thalamocortical circuit consists of reciprocal connections between the thalamus and cortex. The cortex sends strong excitatory feedback to the thalamus, however the function of which is unclear. In this study, we investigated the role of the thalamic metabotropic glutamate receptor 1 (mGluR1)-phospholipase C β4 (PLCβ4) pathway in sleep control in PLCβ4-deficient (PLCβ4-/-) mice. The thalamic mGluR1-PLCβ4 pathway contains synapses that receive corticothalamic inputs. In PLCβ4-/- mice, the transition from wakefulness to the NREM sleep state was stimulated, and the NREM sleep state was stabilized, which resulted in increased NREM sleep. The power density of delta (δ) waves increased in parallel with the increased NREM sleep. These sleep phenotypes in PLCβ4-/- mice were consistent in TC-restricted PLCβ4 knockdown mice. Moreover, in vitro intrathalamic oscillations were greatly enhanced in the PLCβ4-/- slices. The results of our study showed that thalamic mGluR1-PLCβ4 pathway was critical in controlling sleep architecture. -
dc.identifier.bibliographicCitation MOLECULAR BRAIN, v.9, no.1, pp.100 -
dc.identifier.doi 10.1186/s13041-016-0276-5 -
dc.identifier.issn 1756-6606 -
dc.identifier.scopusid 2-s2.0-85006409375 -
dc.identifier.uri -
dc.identifier.url -
dc.identifier.wosid 000390493000001 -
dc.language 영어 -
dc.publisher BIOMED CENTRAL LTD -
dc.title The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture -
dc.type Article -
dc.description.isOpenAccess TRUE -
dc.relation.journalWebOfScienceCategory Neurosciences -
dc.relation.journalResearchArea Neurosciences & Neurology -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor Sleep -
dc.subject.keywordAuthor Thalamus -
dc.subject.keywordAuthor Phospholipase C beta 4 -
dc.subject.keywordAuthor Knockout mice -
dc.subject.keywordAuthor Delta wave -
dc.subject.keywordAuthor Thalamocortical oscillation -
dc.subject.keywordPlus PHOSPHOLIPASE-C BETA-4 -
dc.subject.keywordPlus REM-SLEEP -
dc.subject.keywordPlus THALAMOCORTICAL NEURONS -
dc.subject.keywordPlus DISTINGUISHING DRIVERS -
dc.subject.keywordPlus GABAERGIC NEURONS -
dc.subject.keywordPlus MESSENGER-RNA -
dc.subject.keywordPlus CA2+ CHANNELS -
dc.subject.keywordPlus IN-VITRO -
dc.subject.keywordPlus OSCILLATION -


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