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김성필

Kim, Sung-Phil
Brain-Computer Interface Lab.
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Analysis of Nociceptive Information Encoded in the Temporal Discharge Patterns of Cutaneous C-Fibers

Author(s)
Cho, KyungwonJang, Jun HoKim, Sung-PhilLee, SHChung, Soon-CheolKim, In YoungJang, Dong PyoJung, Sung Jun
Issued Date
2016-11
DOI
10.3389/fncom.2016.00118
URI
https://scholarworks.unist.ac.kr/handle/201301/21006
Fulltext
http://journal.frontiersin.org/article/10.3389/fncom.2016.00118/full
Citation
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE, v.10, pp.118
Abstract
The generation of pain signals from primary afferent neurons is explained by a labeled-line code. However, this notion cannot apply in a simple way to cutaneous C-fibers, which carry signals from a variety of receptors that respond to various stimuli including agonist chemicals. To represent the discharge patterns of C-fibers according to different agonist chemicals, we have developed a quantitative approach using three consecutive spikes. By using this method, the generation of pain in response to chemical stimuli is shown to be dependent on the temporal aspect of the spike trains. Furthermore, under pathological conditions, gamma-aminobutyric acid resulted in pain behavior without change of spike number but with an altered discharge pattern. Our results suggest that information about the agonist chemicals may be encoded in specific temporal patterns of signals in C-fibers, and nociceptive sensation may be influenced by the extent of temporal summation originating from the temporal patterns.
Publisher
FRONTIERS RES FOUND
ISSN
1662-5188
Keyword (Author)
temporal decodingtemporal encodingspike train analysisdischarge patternnociception
Keyword
DORSAL-ROOT-GANGLIANEUROPATHIC PAINMODELNERVEGABADEPOLARIZATIONFREQUENCYSTIMULINEURONSTISSUE

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