Full metadata record
DC Field | Value | Language |
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dc.citation.startPage | 35732 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 6 | - |
dc.contributor.author | Kim, Kwang-Youn Kim | - |
dc.contributor.author | Jang, Hyun-Jun | - |
dc.contributor.author | Yang, Yong Ryul | - |
dc.contributor.author | Park, Kwang-Il | - |
dc.contributor.author | Seo, Jeong Kon | - |
dc.contributor.author | Shin, Il-Woo | - |
dc.contributor.author | Jeon, Tae-Il | - |
dc.contributor.author | Ahn, Soon-cheol | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Osborne, Timothy F. | - |
dc.contributor.author | Seo, Young Kyo | - |
dc.date.accessioned | 2023-12-21T23:10:08Z | - |
dc.date.available | 2023-12-21T23:10:08Z | - |
dc.date.created | 2016-10-27 | - |
dc.date.issued | 2016-10 | - |
dc.description.abstract | Dysregulated autophagy is associated with steatosis and non-alcoholic fatty liver disease (NAFLD), however the mechanisms connecting them remain poorly understand. Here, we show that co-administration of lovastatin and ezetimibe (L/E) significantly reverses hepatic triglyceride accumulation concomitant with an increase in SREBP-2 driven autophagy in mice fed a high-fat diet (HFD). We further show that the statin mediated increase in SREBP-2 directly activates expression of patatin-like phospholipase domain-containing enzyme 8 (PNPLA8) gene, and PNPLA8 associates with autophagosomes and is associated with a decrease in cellular triglyceride. Moreover, we show that over-expression of PNPLA8 dramatically decreases hepatic steatosis through increased autophagy in hepatocytes of HFD-fed mice. Live-cell imaging analyses also reveal that PNPLA8 dynamically interacts with LC3 and we suggest that the SREBP-2/PNPLA8 axis represents a novel regulatory mechanism for lipid homeostasis. These data provide a possible mechanism for the reported beneficial effects of statins for decreasing hepatic triglyceride levels in NAFLD patients. | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.6, pp.35732 | - |
dc.identifier.doi | 10.1038/srep35732 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.scopusid | 2-s2.0-84992375332 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20666 | - |
dc.identifier.url | http://www.nature.com/articles/srep35732 | - |
dc.identifier.wosid | 000385821000001 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | FAMILY-MEMBERS | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | OVERWEIGHT | - |
dc.subject.keywordPlus | MICROSCOPY | - |
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