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DC Field | Value | Language |
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dc.citation.endPage | 1352 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1340 | - |
dc.citation.title | MUCOSAL IMMUNOLOGY | - |
dc.citation.volume | 9 | - |
dc.contributor.author | Ruane, D. | - |
dc.contributor.author | Do, Y | - |
dc.contributor.author | Brane, L. | - |
dc.contributor.author | Garg, A. | - |
dc.contributor.author | Bozzacco, L. | - |
dc.contributor.author | Kraus, T. | - |
dc.contributor.author | Caskey, M. | - |
dc.contributor.author | Salazar, A. | - |
dc.contributor.author | Trumpheller, C. | - |
dc.contributor.author | Mehandru, S. | - |
dc.date.accessioned | 2023-12-21T23:13:41Z | - |
dc.date.available | 2023-12-21T23:13:41Z | - |
dc.date.created | 2016-09-30 | - |
dc.date.issued | 2016-09 | - |
dc.description.abstract | Despite significant therapeutic advances for HIV-1 infected individuals, a preventative HIV-1 vaccine remains elusive. Studies focusing on early transmission events, including the observation that there is a profound loss of gastrointestinal (GI) CD4(+) Tcells during acute HIV-1 infection, highlight the importance of inducing HIV-specific immunity within the gut. Here we report on the generation of cellular and humoral immune responses in the intestines by a mucosally administered, dendritic cell (DC) targeted vaccine. Our results show that nasally delivered alpha-CD205-p24 vaccine in combination with polyICLC, induced polyfunctional immune responses within naso-pulmonary lymphoid sites that disseminated widely to systemic and mucosal (GI tract and the vaginal epithelium) sites. Qualitatively, while alpha-CD205-p24 prime-boost immunization generated CD4(+) T-cell responses, heterologous prime-boost immunization with alpha-CD205-p24 and NYVAC gag-p24 generated high levels of HIV-specific CD4(+) and CD8(+) Tcells within the GI tract. Finally, DC-targeting enhanced the amplitude and longevity of vaccine-induced immune responses in the GI tract. This is the first report of a nasally delivered, DC-targeted vaccine to generate HIV-specific immune responses in the GI tract and will potentially inform the design of preventative approaches against HIV-1 and other mucosal infections | - |
dc.identifier.bibliographicCitation | MUCOSAL IMMUNOLOGY, v.9, no.5, pp.1340 - 1352 | - |
dc.identifier.doi | 10.1038/mi.2015.133 | - |
dc.identifier.issn | 1933-0219 | - |
dc.identifier.scopusid | 2-s2.0-84971329650 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20511 | - |
dc.identifier.url | http://www.nature.com/mi/journal/v9/n5/full/mi2015133a.html | - |
dc.identifier.wosid | 000382319200020 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | A dendritic cell targeted vaccine induces long-term HIV-specific immunity within the gastrointestinal tract | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | CD8(+) T-CELLS | - |
dc.subject.keywordPlus | BROADLY NEUTRALIZING ANTIBODIES | - |
dc.subject.keywordPlus | TEST-OF-CONCEPT | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | DEC-205 RECEPTOR | - |
dc.subject.keywordPlus | HUMANIZED MICE | - |
dc.subject.keywordPlus | RHESUS-MONKEYS | - |
dc.subject.keywordPlus | GAG PROTEIN | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | CORRELATES ANALYSIS | - |
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