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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 981 | - |
dc.citation.number | 6251 | - |
dc.citation.startPage | 977 | - |
dc.citation.title | SCIENCE | - |
dc.citation.volume | 349 | - |
dc.contributor.author | Lee, Ja Yil | - |
dc.contributor.author | Terakawa, Tsuyoshi | - |
dc.contributor.author | Qi, Zhi | - |
dc.contributor.author | Steinfeld, Justin B. | - |
dc.contributor.author | Redding, Sy | - |
dc.contributor.author | Kwon, YoungHo | - |
dc.contributor.author | Gaines, William A. | - |
dc.contributor.author | Zhao, Weixing | - |
dc.contributor.author | Sung, Patrick | - |
dc.contributor.author | Greene, Eric C. | - |
dc.date.accessioned | 2023-12-22T00:48:33Z | - |
dc.date.available | 2023-12-22T00:48:33Z | - |
dc.date.created | 2016-09-30 | - |
dc.date.issued | 2015-08 | - |
dc.description.abstract | DNA strand exchange plays a central role in genetic recombination across all kingdoms of life, but the physical basis for these reactions remains poorly defined. Using single-molecule imaging, we found that bacterial RecA and eukaryotic Rad51 and Dmc1 all stabilize strand exchange intermediates in precise three-nucleotide steps. Each step coincides with an energetic signature (0.3 kBT) that is conserved from bacteria to humans. Triplet recognition is strictly dependent on correct Watson-Crick pairing. Rad51, RecA, and Dmc1 can all step over mismatches, but only Dmc1 can stabilize mismatched triplets. This finding provides insight into why eukaryotes have evolved a meiosis-specific recombinase. We propose that canonical Watson-Crick base triplets serve as the fundamental unit of pairing interactions during DNA recombination | - |
dc.identifier.bibliographicCitation | SCIENCE, v.349, no.6251, pp.977 - 981 | - |
dc.identifier.doi | 10.1126/science.aab2666 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.scopusid | 2-s2.0-84940553739 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20494 | - |
dc.identifier.url | http://science.sciencemag.org/content/349/6251/977 | - |
dc.identifier.wosid | 000360646800054 | - |
dc.language | 영어 | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Base triplet stepping by the Rad51/RecA family of recombinases | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | STRAND EXCHANGE | - |
dc.subject.keywordPlus | HOMOLOGOUS RECOMBINATION | - |
dc.subject.keywordPlus | MEIOTIC RECOMBINATION | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | FILAMENTS | - |
dc.subject.keywordPlus | YEAST | - |
dc.subject.keywordPlus | DMC1 | - |
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