Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.number | 8 | - |
dc.citation.startPage | 240 | - |
dc.citation.title | TOXINS | - |
dc.citation.volume | 8 | - |
dc.contributor.author | Moon, young-Sun. | - |
dc.contributor.author | Choi, Won-Sik | - |
dc.contributor.author | Park, Eun-Sil | - |
dc.contributor.author | Bae, In Kyung | - |
dc.contributor.author | Choi, Sung-Deuk | - |
dc.contributor.author | Paek, Ockjin | - |
dc.contributor.author | Kim, Sheen-Hee | - |
dc.contributor.author | Chun, Hyang Sook | - |
dc.contributor.author | Lee, Sung-Eun | - |
dc.date.accessioned | 2023-12-21T23:18:15Z | - |
dc.date.available | 2023-12-21T23:18:15Z | - |
dc.date.created | 2016-09-02 | - |
dc.date.issued | 2016-08 | - |
dc.description.abstract | Twelve methylenedioxy-containing compounds including piperine and 10 piperine-like synthetic compounds were assessed to determine their antifungal and antiaflatoxigenic activities against Aspergillus flavus ATCC 22546 in terms of their structure-activity relationships. Piperonal and 1,3-benzodioxole had inhibitory effects against A. flavus mycelial growth and aflatoxin B1 production up to a concentration of 1000 mu g/mL. Ten piperine-like synthetic compounds were synthesized that differed in terms of the carbon length in the hydrocarbon backbone and the presence of the methylenedioxy moiety. In particular, 1-(2-methylpiperidin-1-yl)-3-phenylprop-2-en-1-one had potent antifungal and antiaflatoxigenic effects against A. flavus up to a concentration of 1 mu g/mL. This synthetic compound was remarkable because the positive control thiabendazole had no inhibitory effect at this concentration. Reverse transcription-PCR analysis showed that five genes involved in aflatoxin biosynthesis pathways were down-regulated in A. flavus, i.e., aflD, aflK, aflQ, aflR, and aflS; therefore, the synthetic compound inhibited aflatoxin production by down-regulating these genes. | - |
dc.identifier.bibliographicCitation | TOXINS, v.8, no.8, pp.240 | - |
dc.identifier.doi | 10.3390/toxins8080240 | - |
dc.identifier.issn | 2072-6651 | - |
dc.identifier.scopusid | 2-s2.0-84983032255 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20415 | - |
dc.identifier.url | http://www.mdpi.com/2072-6651/8/8/240 | - |
dc.identifier.wosid | 000382268800014 | - |
dc.language | 영어 | - |
dc.publisher | MDPI AG | - |
dc.title | Antifungal and antiaflatoxigenic methylenedioxy-containing compounds and piperine-like synthetic compounds | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology; Toxicology | - |
dc.relation.journalResearchArea | Food Science & Technology; Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | aflatoxin | - |
dc.subject.keywordAuthor | Aspergillus flavus | - |
dc.subject.keywordAuthor | methylenedioxy compounds | - |
dc.subject.keywordAuthor | piperine | - |
dc.subject.keywordAuthor | reverse transcription-PCR | - |
dc.subject.keywordPlus | ASPERGILLUS-PARASITICUS GROWTH | - |
dc.subject.keywordPlus | MYCOTOXIN CONTAMINATION | - |
dc.subject.keywordPlus | AFLATOXIN B-1 | - |
dc.subject.keywordPlus | ESSENTIAL OIL | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | DETOXIFICATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | REDUCTION | - |
dc.subject.keywordPlus | L. | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.