Full metadata record
DC Field | Value | Language |
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dc.citation.startPage | 32647 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 6 | - |
dc.contributor.author | Lee, Jae-Hyeok | - |
dc.contributor.author | Baek, Sun-Yong | - |
dc.contributor.author | Song, YoungKyu | - |
dc.contributor.author | Lim, Sujeong | - |
dc.contributor.author | Lee, Hansol | - |
dc.contributor.author | Nguyen, Minh Phuong | - |
dc.contributor.author | Kim, Eun-Joo | - |
dc.contributor.author | Huh, Gi Yeong | - |
dc.contributor.author | Chun, Se Young | - |
dc.contributor.author | Cho, Hyungjoon | - |
dc.date.accessioned | 2023-12-21T23:14:17Z | - |
dc.date.available | 2023-12-21T23:14:17Z | - |
dc.date.created | 2016-09-08 | - |
dc.date.issued | 2016-09 | - |
dc.description.abstract | High field magnetic resonance imaging (MRI)-based delineation of the substantia nigra (SN) and visualization of its inner cellular organization are promising methods for the evaluation of morphological changes associated with neurodegenerative diseases; however, corresponding MR contrasts must be matched and validated with quantitative histological information. Slices from two postmortem SN samples were imaged with a 7 Tesla (7T) MRI with T1 and T2* imaging protocols and then stained with Perl’s Prussian blue, Kluver-Barrera, tyrosine hydroxylase, and calbindin immunohistochemistry in a serial manner. The association between T2* values and quantitative histology was investigated with a co-registration method that accounts for histology slice preparation. The ventral T2* hypointense layers between the SNr and the crus cerebri extended anteriorly to the posterior part of the crus cerebri, which demonstrates the difficulty with an MRI-based delineation of the SN. We found that the paramagnetic hypointense areas within the dorsolateral SN corresponded to clusters of neuromelanin (NM). These NM-rich zones were distinct from the hypointense ventromedial regions with high iron pigments. Nigral T2* imaging at 7T can reflect the density of NM-containing neurons as the metal-bound NM macromolecules may decrease T2* values and cause hypointense signalling in T2* imaging at 7T. | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.6, pp.32647 | - |
dc.identifier.doi | 10.1038/srep32647 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.scopusid | 2-s2.0-84986226558 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20414 | - |
dc.identifier.url | http://www.nature.com/articles/srep32647 | - |
dc.identifier.wosid | 000382464500001 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | The Neuromelanin-related T2* Contrast in Postmortem Human Substantia Nigra with 7T MRI | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | LOCUS-CERULEUS | - |
dc.subject.keywordPlus | SENSITIVE MRI | - |
dc.subject.keywordPlus | HUMAN BRAIN | - |
dc.subject.keywordPlus | PATHOLOGY | - |
dc.subject.keywordPlus | HISTOLOGY | - |
dc.subject.keywordPlus | IMAGES | - |
dc.subject.keywordPlus | SIGNAL | - |
dc.subject.keywordPlus | TIMES | - |
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