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DC Field | Value | Language |
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dc.citation.endPage | 207 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 201 | - |
dc.citation.title | JOURNAL OF BIOTECHNOLOGY | - |
dc.citation.volume | 168 | - |
dc.contributor.author | Jeon, Byoung Wook | - |
dc.contributor.author | Lee, Jumin | - |
dc.contributor.author | Kim, Hyun Sook | - |
dc.contributor.author | Cho, Dae Haeng | - |
dc.contributor.author | Lee, Hyuk | - |
dc.contributor.author | Chang, Rakwoo | - |
dc.contributor.author | Kim, Yong Hwan | - |
dc.date.accessioned | 2023-12-22T03:36:17Z | - |
dc.date.available | 2023-12-22T03:36:17Z | - |
dc.date.created | 2016-09-06 | - |
dc.date.issued | 2013-10 | - |
dc.description.abstract | R-lactide, a pivotal monomer for the production of poly (D-lactic acid) (PDLA) or stereocomplex poly (lactic acid) (PLA) was synthesized from alkyl (R)-lactate through a lipase-catalyzed reaction without racemization. From among several types of lipase, only lipase B from Candida antarctica (Novozym 435; CAL-B) was effective in the reaction that synthesized (R,R)-lactide. Enantiopure (R,R)-lactide, which consisted of over 99% enantiomeric excess, was synthesized from methyl (R)-lactate through CAL-B catalysis. Removal of the methanol by-product was critical to obtain a high level of lactide conversion. The (R, R)lactide yield was 56% in a reaction containing 100 mg of Novozym 435, 10 mM methyl (R)-lactate and 1500 mg of molecular sieve 5 A in methyl tert-butyl ether (MTBE). The important monomer (R,R)-lactide that is required for the production of the widely recognized bio-plastic PDLA and the PLA stereocomplex can be obtained using this novel synthetic method. | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOTECHNOLOGY, v.168, no.2, pp.201 - 207 | - |
dc.identifier.doi | 10.1016/j.jbiotec.2013.06.021 | - |
dc.identifier.issn | 0168-1656 | - |
dc.identifier.scopusid | 2-s2.0-84885870929 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20351 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0168165613002770 | - |
dc.identifier.wosid | 000325978300011 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Lipase-catalyzed enantioselective synthesis of (R,R)-lactide from alkyl lactate to produce PDLA (poly D-lactic acid) and stereocomplex PLA (poly lactic acid) | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | (R,R)-lactide | - |
dc.subject.keywordAuthor | Alkyl (R)-lactate | - |
dc.subject.keywordAuthor | Lipase | - |
dc.subject.keywordAuthor | Novozym 435 | - |
dc.subject.keywordAuthor | Molecular sieve | - |
dc.subject.keywordPlus | POLYMERIZATION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | SELECTIVITY | - |
dc.subject.keywordPlus | MECHANISM | - |
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