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- Kim, Yong Hwan
- Enzyme and Protein Engineering Lab.
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| DC Field | Value | Language |
|---|---|---|
| dc.citation.endPage | 14539 | - |
| dc.citation.number | 77 | - |
| dc.citation.startPage | 14536 | - |
| dc.citation.title | CHEMICAL COMMUNICATIONS | - |
| dc.citation.volume | 51 | - |
| dc.contributor.author | Quang Anh Tuan Le | - |
| dc.contributor.author | Chang, Rakwoo | - |
| dc.contributor.author | Kim, Yong Hwan | - |
| dc.date.accessioned | 2023-12-22T00:48:36Z | - |
| dc.date.available | 2023-12-22T00:48:36Z | - |
| dc.date.created | 2016-09-06 | - |
| dc.date.issued | 2015-08 | - |
| dc.description.abstract | A rational design of paraoxonase 1 based on molecular docking discovered H115W/T332S and I74F/H115W/T332S mutants exhibited a 40-fold increase in catalytic efficiency (k(cat)/K-m) toward the hydrolysis of two toxic and popular organophosphates (diethyl-paraoxon and dimethyl-paraoxon). Moreover, the conversion of the paraoxons (741.3-825.6 mg L-1) by the evolved mutants was 42-60-fold faster than that by the wild type | - |
| dc.identifier.bibliographicCitation | CHEMICAL COMMUNICATIONS, v.51, no.77, pp.14536 - 14539 | - |
| dc.identifier.doi | 10.1039/c5cc05857k | - |
| dc.identifier.issn | 1359-7345 | - |
| dc.identifier.scopusid | 2-s2.0-84941710281 | - |
| dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20328 | - |
| dc.identifier.url | http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC05857K#!divAbstract | - |
| dc.identifier.wosid | 000361206000028 | - |
| dc.language | 영어 | - |
| dc.publisher | ROYAL SOC CHEMISTRY | - |
| dc.title | Rational design of paraoxonase 1 (PON1) for the efficient hydrolysis of organophosphates | - |
| dc.type | Article | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.subject.keywordPlus | EXPRESSION | - |
| dc.subject.keywordPlus | PROTECTS | - |
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