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DC Field | Value | Language |
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dc.citation.endPage | 2185 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2177 | - |
dc.citation.title | ACS CHEMICAL BIOLOGY | - |
dc.citation.volume | 11 | - |
dc.contributor.author | Park, Jong-Seok | - |
dc.contributor.author | Nam, Eunju | - |
dc.contributor.author | Lee, Hye-Kyeong | - |
dc.contributor.author | Lim, Mi Hee | - |
dc.contributor.author | Rhee, Hyun-Woo | - |
dc.date.accessioned | 2023-12-21T23:19:14Z | - |
dc.date.available | 2023-12-21T23:19:14Z | - |
dc.date.created | 2016-08-20 | - |
dc.date.issued | 2016-08 | - |
dc.description.abstract | Bilirubin (BR) is a de novo synthesized metabolite of human cells. However, subcellular localization of BR in the different organelles of human cells has been largely unknown. Here, utilizing UnaG as a genetically encoded fluorescent BR sensor, we report the existence of relatively BR-enriched and BR-depleted microspaces in various cellular organelles of live cells. Our studies indicate that (i) the cytoplasmic facing membrane of the endoplasmic reticulum (ER) and the nucleus are relatively BR-enriched spaces and (ii) mitochondrial intermembrane space and the ER lumen are relatively BR-depleted spaces. Thus, we demonstrate a relationship between such asymmetrical BR distribution in the ER membrane and the BR metabolic pathway. Furthermore, our results suggest plausible BR-transport and BR-regulating machineries in other cellular compartments, including the nucleus and mitochondria. | - |
dc.identifier.bibliographicCitation | ACS CHEMICAL BIOLOGY, v.11, no.8, pp.2177 - 2185 | - |
dc.identifier.doi | 10.1021/acschembio.6b00017 | - |
dc.identifier.issn | 1554-8929 | - |
dc.identifier.scopusid | 2-s2.0-84983315286 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20305 | - |
dc.identifier.url | http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00017 | - |
dc.identifier.wosid | 000381847700013 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | In Cellulo Mapping of Subcellular Localized Bilirubin | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | IMAGING HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | LIVING CELLS | - |
dc.subject.keywordPlus | FLUORESCENT-PROBES | - |
dc.subject.keywordPlus | FUSION PROTEINS | - |
dc.subject.keywordPlus | LIVE CELLS | - |
dc.subject.keywordPlus | SENSORS | - |
dc.subject.keywordPlus | ALBUMIN | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | SIGNAL | - |
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