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Kim, Jiyun
School of Materials Science and Engineering
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One-step pipetting and assembly of encoded chemical-laden microparticles for high-throughput multiplexed bioassays

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Title
One-step pipetting and assembly of encoded chemical-laden microparticles for high-throughput multiplexed bioassays
Author
Chung, Su EunKim, JiyunOh, Dong YoonSong, YounghoonLee, Sung HoonMin, SeungkiKwon, Sunghoon
Issue Date
2014-03
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE COMMUNICATIONS, v.5, no., pp.3468 -
Abstract
One quantitative liquid handling method in conventional assay processes is pipetting, which delivers a precise volume of one sample at a time. As this process becomes laborious and time-consuming as the number of samples increases, researchers in individual laboratories need a way to conduct large-scale assays in a reasonable amount of time and at an affordable cost. Here we report a novel handling technique of chemical substances termed 'partipetting', which allows the one-step pipetting of various chemical-laden hydrogels. We pipette and assemble various types of encoded chemical-laden microparticles in microwell arrays in parallel. The combination of this heterogeneous particle chip and a cell chip induces the release of the chemicals from the hydrogels and, eventually, the chemicals treat the targets. Based on bioassay applications using partipetting, we show its capability in large-scale bioassays, without the need for high-throughput bioassay resources, owing to a reduction in the assay costs and time.
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DOI
10.1038/ncomms4468
ISSN
2041-1723
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MSE_Journal Papers
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