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DC Field | Value | Language |
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dc.citation.endPage | 6281 | - |
dc.citation.number | 37 | - |
dc.citation.startPage | 6272 | - |
dc.citation.title | ONCOGENE | - |
dc.citation.volume | 23 | - |
dc.contributor.author | Park, SS | - |
dc.contributor.author | Eom, YW | - |
dc.contributor.author | Kim, Eunhee | - |
dc.contributor.author | Lee, JH | - |
dc.contributor.author | Min, DS | - |
dc.contributor.author | Kim, S | - |
dc.contributor.author | Kim, SJ | - |
dc.contributor.author | Choi, KS | - |
dc.date.accessioned | 2023-12-22T10:44:06Z | - |
dc.date.available | 2023-12-22T10:44:06Z | - |
dc.date.created | 2016-08-02 | - |
dc.date.issued | 2004-08 | - |
dc.description.abstract | Transforming growth factor-beta1 (TGF-beta1) is a potent inducer of apoptosis in normal hepatocytes, and acquiring resistance to TGF-beta1 may be a critical step in the development of hepatocellular carcinoma (HCC). In this study, we investigated the possible involvement of c-Src in the regulation of TGF-beta1-induced apoptosis. TGF-beta1 induced transient activation of c-Src and its subsequent caspase-mediated degradation concomitant with cell death in FaO hepatoma cells, which are sensitive to TGF-beta1. In response to TGF-beta1, activated c-Src was translocated into the cytoplasmic membrane, then relocated to the nuclei of apoptotic cells during its cleavage. In TGF-beta1-induced apoptotic cells, c-Src maintained its tight association with p85 FAK fragment cleaved by caspases, possibly contributing to focal adhesion disassembly. TGF-beta1-induced apoptosis was enhanced by either inhibition of c-Src activity using PP1 or PP2, or by overexpression of dominant-negative c-Src. In contrast, overexpression of constitutively active c-Src inhibited apoptosis suppressing TGF-beta1-induced activation of p38, JNK and caspases. In many HCC cell lines resistant to TGF-beta1, enhanced c-Src activity was detected. We hypothesize that activated c-Src in HCC may contribute to resistance against the apoptotic and/or antiproliferative properties of TGF-beta1 | - |
dc.identifier.bibliographicCitation | ONCOGENE, v.23, no.37, pp.6272 - 6281 | - |
dc.identifier.doi | 10.1038/sj.onc.1207856 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.scopusid | 2-s2.0-4344701752 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20187 | - |
dc.identifier.url | http://www.nature.com/onc/journal/v23/n37/full/1207856a.html | - |
dc.identifier.wosid | 000223399000011 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Involvement of c-Src kinase in the regulation of TGF-beta 1-induced apoptosis | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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