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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 78 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 76 | - |
dc.citation.title | AUTOPHAGY | - |
dc.citation.volume | 4 | - |
dc.contributor.author | Kim, Eun Hee | - |
dc.contributor.author | Choi, Kyeong Sook | - |
dc.date.accessioned | 2023-12-22T09:06:09Z | - |
dc.date.available | 2023-12-22T09:06:09Z | - |
dc.date.created | 2016-08-02 | - |
dc.date.issued | 2008-01 | - |
dc.description.abstract | Mitochondria, which are a major source of intracellular reactive oxygen species (ROS), are extremely vulnerable to oxidative stress. We recently reported that selenite treatment of various glioma cells induced a non-apoptotic cell death accompanied by excessive mitophagy (selective autophagy of damaged mitochondria). Examination of various ROS revealed that the superoxide anion played a key role in selenite-induced mitochondrial damage, mitophagy and cell death. Treatment with superoxide generators (diquat and paraquat) was sufficient to trigger mitophagy in glioma cells. Small interfering RNA-mediated knockdown of ATG6 or ATG7 attenuated selenite-induced mitophagy and cell death, demonstrating that the mitophagic pathway contributes to selenite-induced cell death. The effect of selenite in glioma cells may thus provide an example of superoxide-mediated mitophagic cell death, i.e., cell death caused by excessive mitophagy | - |
dc.identifier.bibliographicCitation | AUTOPHAGY, v.4, no.1, pp.76 - 78 | - |
dc.identifier.issn | 1554-8627 | - |
dc.identifier.scopusid | 2-s2.0-38049018438 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20180 | - |
dc.identifier.url | http://www.tandfonline.com/doi/abs/10.4161/auto.5119#.V6FAX9KLRpg | - |
dc.identifier.wosid | 000252211800013 | - |
dc.language | 영어 | - |
dc.publisher | LANDES BIOSCIENCE | - |
dc.title | A critical role of superoxide anion in selenite-induced mitophagic cell death | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | selenite | - |
dc.subject.keywordAuthor | mitophagy | - |
dc.subject.keywordAuthor | autophagic cell death | - |
dc.subject.keywordAuthor | superoxide | - |
dc.subject.keywordAuthor | cancer therapy | - |
dc.subject.keywordPlus | AUTOPHAGY | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | DEGRADATION | - |
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