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DC Field | Value | Language |
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dc.citation.endPage | 701 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 690 | - |
dc.citation.title | NMR IN BIOMEDICINE | - |
dc.citation.volume | 29 | - |
dc.contributor.author | Jung H.S. | - |
dc.contributor.author | Jin S.H. | - |
dc.contributor.author | Cho, J.H. | - |
dc.contributor.author | Han S.H. | - |
dc.contributor.author | Lee D.K. | - |
dc.contributor.author | Cho, Hyungjoon | - |
dc.date.accessioned | 2023-12-21T23:39:48Z | - |
dc.date.available | 2023-12-21T23:39:48Z | - |
dc.date.created | 2016-07-07 | - |
dc.date.issued | 2016-06 | - |
dc.description.abstract | The ability to visualize whole-brain vasculature is important for quantitative in vivo investigation of vascular malfunctions in cerebral small vessel diseases, including cancer, stroke and neurodegeneration. Transverse relaxation-based Delta R-2 and Delta R-2* MR angiography (MRA) provides improved vessel-tissue contrast in animal deep brain with the aid of intravascular contrast agents; however, it is susceptible to orientation dependence, air-tissue interface artifacts and vessel size overestimation. Dual-mode MRA acquisition with superparamagnetic iron oxide nanoparticles (SPION) provides a unique opportunity to systematically compare and synergistically combine both longitudinal (R-1) and transverse (Delta R-2 and Delta R-2*) relaxation-based MRA. Through Monte Carlo (MC) simulation and MRA experiments in normal and tumor-bearing animals with intravascular SPION, we show that ultrashort TE (UTE) MRA acquires well-defined vascularization on the brain surface, minimizing air-tissue artifacts, and combined Delta R-2 and Delta R-2* MRA simultaneously improves the sensitivity to intracortical penetrating vessels and reduces vessel size overestimation. Consequently, UTE-Delta R-2-Delta R-2* combined MRA complements the shortcomings of individual angiograms and provides a strategy to synergistically merge longitudinal and transverse relaxation effects to generate more robust in vivo whole-brain micro-MRA. | - |
dc.identifier.bibliographicCitation | NMR IN BIOMEDICINE, v.29, no.6, pp.690 - 701 | - |
dc.identifier.doi | 10.1002/nbm.3514 | - |
dc.identifier.issn | 0952-3480 | - |
dc.identifier.scopusid | 2-s2.0-84979488425 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/19981 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/nbm.3514/abstract | - |
dc.identifier.wosid | 000379029300001 | - |
dc.language | 영어 | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | UTE-Delta R-2-Delta R-2* combined MR whole-brain angiogram using dual-contrast superparamagnetic iron oxide nanoparticles | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biophysics; Radiology, Nuclear Medicine & Medical Imaging; Spectroscopy | - |
dc.relation.journalResearchArea | Biophysics; Radiology, Nuclear Medicine & Medical Imaging; Spectroscopy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | micro-MR angiography | - |
dc.subject.keywordAuthor | dual-contrast SPION | - |
dc.subject.keywordAuthor | ultrashort echo | - |
dc.subject.keywordPlus | PERMEABILITY | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE ANGIOGRAPHY | - |
dc.subject.keywordPlus | CEREBRAL BLOOD-VOLUME | - |
dc.subject.keywordPlus | SUSCEPTIBILITY ARTIFACTS | - |
dc.subject.keywordPlus | TUMOR ANGIOGENESIS | - |
dc.subject.keywordPlus | MICRO-MRI | - |
dc.subject.keywordPlus | VISUALIZATION | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | MICROVASCULATURE | - |
dc.subject.keywordPlus | QUANTIFICATION | - |
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