Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix
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- Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix
- Kanapathipillai, Mathumai; Mammoto, Akiko; Mammoto, Tadanori; Kang, Joo H.; Jiang, Elisabeth; Ghosh, Kaustabh; Korin, Netanel; Gibbs, Ashley; Mannix, Robert; Ingber, Donald E.
- Cancer; nanoparticle; lysyl oxidase; extracellular matrix; mechanics
- Issue Date
- AMER CHEMICAL SOC
- NANO LETTERS, v.12, no.6, pp.3213 - 3217
- A cancer nanotherapeutic has been developed that targets the extracellular matrix (ECM)-modifying enzyme lysyl oxidase (LOX) and alters the ECM structure. Poly(D,L-lactide-co-glycolide) nanoparticles (similar to 220 nm) coated with a LOX inhibitory antibody bind to ECM and suppress mammary cancer cell growth and invasion in vitro as well as tumor expansion in vivo, with greater efficiency than soluble anti-LOX antibody. This nanomaterials approach opens a new path for treating cancer with higher efficacy and decreased side effects.
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