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Kang, Joo H.
Translational Multiscale Biofluidics Lab (TMB Lab)
Research Interests
  • Biomedical devices, infectious disease, organ-on-a-chip, microfluidics, mechanobiology

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Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix

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Title
Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix
Author
Kanapathipillai, MathumaiMammoto, AkikoMammoto, TadanoriKang, Joo H.Jiang, ElisabethGhosh, KaustabhKorin, NetanelGibbs, AshleyMannix, RobertIngber, Donald E.
Keywords
Cancer; nanoparticle; lysyl oxidase; extracellular matrix; mechanics
Issue Date
2012-05
Publisher
AMER CHEMICAL SOC
Citation
NANO LETTERS, v.12, no.6, pp.3213 - 3217
Abstract
A cancer nanotherapeutic has been developed that targets the extracellular matrix (ECM)-modifying enzyme lysyl oxidase (LOX) and alters the ECM structure. Poly(D,L-lactide-co-glycolide) nanoparticles (similar to 220 nm) coated with a LOX inhibitory antibody bind to ECM and suppress mammary cancer cell growth and invasion in vitro as well as tumor expansion in vivo, with greater efficiency than soluble anti-LOX antibody. This nanomaterials approach opens a new path for treating cancer with higher efficacy and decreased side effects.
URI
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DOI
10.1021/nl301206p
ISSN
1530-6984
Appears in Collections:
BME_Journal Papers
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