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- Kang, Joo H.
- Translational Multiscale Biofluidics Lab.
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Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix
- Author(s)
- Kanapathipillai, Mathumai, Mammoto, Akiko, Mammoto, Tadanori, Kang, Joo H., Jiang, Elisabeth, Ghosh, Kaustabh, Korin, Netanel, Gibbs, Ashley, Mannix, Robert, Ingber, Donald E.
- Issued Date
- 2012-05
- Citation
- NANO LETTERS, v.12, no.6, pp.3213 - 3217
- Abstract
- A cancer nanotherapeutic has been developed that targets the extracellular matrix (ECM)-modifying enzyme lysyl oxidase (LOX) and alters the ECM structure. Poly(D,L-lactide-co-glycolide) nanoparticles (similar to 220 nm) coated with a LOX inhibitory antibody bind to ECM and suppress mammary cancer cell growth and invasion in vitro as well as tumor expansion in vivo, with greater efficiency than soluble anti-LOX antibody. This nanomaterials approach opens a new path for treating cancer with higher efficacy and decreased side effects.
- Publisher
- AMER CHEMICAL SOC
- ISSN
- 1530-6984
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