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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 893 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 886 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 473 | - |
dc.contributor.author | Yoo, Bum Ho | - |
dc.contributor.author | Park, Chi-Hu | - |
dc.contributor.author | Kim, Hyun-Jun | - |
dc.contributor.author | Kang, Du-Seock | - |
dc.contributor.author | Bae, Chang-Dae | - |
dc.date.accessioned | 2023-12-21T23:45:26Z | - |
dc.date.available | 2023-12-21T23:45:26Z | - |
dc.date.created | 2016-05-09 | - |
dc.date.issued | 2016-05 | - |
dc.description.abstract | Spindle bipolarity is crucial for segregating chromosome during somatic cell division. Previous studies have suggested that cytoskeleton associated protein 2 (CKAP2) is involved in spindle assembly and chromosome segregation. In this study, we show that CKAP2-depleted primary hepatocytes exhibit over-duplicated centrosomes with disjoined chromosomes from metaphase plate. These cells proceed to apoptosis or multipolar cell division and subsequent apoptotic cell death. In addition, a mouse liver regeneration experiment showed a marked decrease in efficiency of hepatic regeneration in CKAP2-depleted liver. These data suggest a physiological role of CKAP2 in the formation of spindle bipolarity, which is necessary for maintaining chromosomal stability. | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.473, no.4, pp.886 - 893 | - |
dc.identifier.doi | 10.1016/j.bbrc.2016.03.145 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.scopusid | 2-s2.0-84962772241 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/19121 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X16304582 | - |
dc.identifier.wosid | 000375823700018 | - |
dc.language | 영어 | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | CKAP2 is necessary to ensure the faithful spindle bipolarity in a dividing diploid hepatocyte | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Biophysics | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Centrosome | - |
dc.subject.keywordAuthor | Chromosome segregation | - |
dc.subject.keywordAuthor | CKAP2 | - |
dc.subject.keywordAuthor | Multipolar cell division | - |
dc.subject.keywordPlus | CYTOSKELETON-ASSOCIATED PROTEIN | - |
dc.subject.keywordPlus | CELL-CYCLE | - |
dc.subject.keywordPlus | CENTROSOMAL PROTEINS | - |
dc.subject.keywordPlus | ASSEMBLY CHECKPOINT | - |
dc.subject.keywordPlus | ANEUPLOIDY | - |
dc.subject.keywordPlus | TMAP/CKAP2 | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CYTOKINESIS | - |
dc.subject.keywordPlus | DUPLICATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
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