The Molecular Taxonomy of Primary Prostate Cancer

Cited 2 times inthomson ciCited 0 times inthomson ci
Title
The Molecular Taxonomy of Primary Prostate Cancer
Author
Abeshouse, AdamAhn, JaeilAkbani, RehanAlly, AdrianAmin, SamirkumarAndry, Christopher D.Annala, MattiAprikian, ArmenArmenia, JoshuaArora, ArshiAuman, J. ToddBalasundaram, MirunaBalu, SaianandBarbieri, Christopher E.Bauer, ThomasBenz, Christopher C.Bergeron, AlainBeroukhim, RameenBerrios, MarioBivol, AdrianBodenheimer, TomBoice, LoriBootwalla, Moiz S.dos Reis, Rodolfo BorgesBoutros, Paul C.Bowen, JayBowlby, ReanneBoyd, JeffreyBradley, Robert K.Breggia, AnneBrimo, FadiBristow, Christopher A.Brooks, DeniseBroom, Bradley M.Bryce, Alan H.Bubley, GlennBurks, EricButterfield, Yaron S. N.Button, MichaelCanes, DavidCarlotti, Carlos G.Carlsen, RebeccaCarmel, MichelCarroll, Peter R.Carter, Scott L.Cartun, RichardCarver, Brett S.Chan, June M.Chang, Matthew T.Chen, YuCherniack, Andrew D.Chevalier, SimoneChin, LyndaCho, JuokChu, AndyChuah, EricChudamani, SudhaCibulskis, KristianCiriello, GiovanniClarke, AmandaCooperberg, Matthew R.Corcoran, Niall M.Costello, Anthony J.Cowan, JanetCrain, DanielCurley, ErinDavid, KerstinDemchok, John A.Demichelis, FrancescaDhalla, NoreenDhir, RajivDoueik, AlexandreDrake, BettinaDvinge, HeidiDyakova, NatalyaFelau, InaFerguson, Martin L.Frazer, ScottFreedland, StephenFu, YaoGabriel, Stacey B.Gao, JianjiongGardner, JohannaGastier-Foster, Julie M.Gehlenborg, NilsGerken, MarkGerstein, Mark B.Getz, GadGodwin, Andrew K.Gopalan, AnuradhaGraefen, MarkusGraim, KileyGribbin, ThomasGuin, RanabirGupta, ManaswiHadjipanayis, AngelaHaider, SyedHamel, LucieHayes, D. NeilHeiman, David I.Hess, JulianHoadley, Katherine A.Holbrook, Andrea H.Holt, Robert A.Holway, AntoniaHovens, Christopher M.Hoyle, Alan P.Huang, MeiHutter, Carolyn M.Ittmann, MichaelIype, LisaJefferys, Stuart R.Jones, Corbin D.Jones, Steven J. M.Juhl, HartmutKahles, AndreKane, Christopher J.Kasaian, KatayoonKerger, MichaelKhurana, EktaKim, JaegilKlein, Robert J.Kucherlapati, RajuLacombe, LouisLadanyi, MarcLai, Phillip H.Laird, Peter W.Lander, Eric S.Latour, MathieuLawrence, Michael S.Lau, KevinLeBien, TuckerLee, DarleneLee, SeminLehmann, Kjong-VanLeraas, Kristen M.Leshchiner, IgnatyLeung, RobertLibertino, John A.Lichtenberg, Tara M.Lin, PeiLinehan, W. MarstonLing, ShiyunLippman, Scott M.Liu, JiaLiu, WenbinLochovsky, LucasLoda, MassimoLogothetis, ChristopherLolla, LaxmiLongacre, TeriLu, YilingLuo, JianhuaMa, YussanneMahadeshwar, Harshad S.Mallery, DavidMariamidze, ArmazMarra, Marco A.Mayo, MichaelMcCall, ShannonMcKercher, GinetteMeng, ShaowuMes-Masson, Anne-MarieMerino, Maria J.Meyersson, MatthewMieczkowski, Piotr A.Mills, Gordon B.Shaw, Kenna R. MillsMinner, SarahMoinzadeh, AlirezaMoore, Richard A.Morris, ScottMorrison, CarlMose, Lisle E.Mungall, Andrew J.Murray, Bradley A.Myers, Jerome B.Naresh, RashiNelson, JoelNelson, Mark A.Nelson, Peter S.Newton, YuliaNoble, Michael S.Noushmehr, HoutanNykter, MattiPantazi, AngelikiParfenov, MichaelPark, Peter J.Parker, Joel S.Paulauskis, JosephPenny, RobertPerou, Charles M.Piche, AlainPihl, ToddPinto, Peter A.Prandi, DavideProtopopov, AlexeiRamirez, Nilsa C.Rao, ArvindRathmell, W. KimrynRaetsch, GunnarRen, XiaojiaReuter, Victor E.Reynolds, Sheila M.Rhie, Suhn K.Rieger-Christ, KimberlyRoach, JeffreyRobertson, A. GordonRobinson, BrianRubin, Mark A.Saad, FredSadeghi, SaraSaksena, GordonSaller, CharlesSalner, AndrewSanchez-Vega, FranciscoSander, ChrisSandusky, GeorgeSauter, GuidoSboner, AndreaScardino, Peter T.Scarlata, EleonoraSchein, Jacqueline E.Schlomm, ThorstenSchmidt, Laura S.Schultz, NikolausSchumacher, Steven E.Seidman, JonathanNeder, LucianoSeth, SahilSharp, AlexisShelton, CandaceShelton, TroyShen, HuiShen, RonglaiSherman, MarkSheth, MargiShi, YanShih, JuliannShmulevich, IlyaSimko, JeffrySimon, RonaldSimons, Janae V.Sipahimalani, PayalSkelly, TaraSofia, Heidi J.Soloway, Matthew G.Song, XingzhiSorcini, AndreaSougnez, CarrieStepa, SergheiStewart, ChipStewart, JohnStuart, Joshua M.Sullivan, Travis B.Sun, CharlieSun, HuandongTam, AngelaTan, DonghuiTang, JiabinTarnuzzer, RoyTarvin, KatherineTaylor, Barry S.Teebagy, PatrickTenggara, ImeldaTetu, BernardTewari, AshutoshThiessen, NinaThompson, TimothyThorne, Leigh B.Tirapelli, Daniela P.Tomlins, Scott A.Trevisan, Felipe AmstaldenTroncoso, PatriciaTrue, Lawrence D.Tsourlakis, Maria ChristinaTyekucheva, SvitlanaVan Allen, EliezerVan den Berg, David J.Veluvolu, UmadeviVerhaak, RoelVocke, Cathy D.Voet, DougWan, YunhuWang, QingguoWang, WenyiWang, ZhiningWeinhold, NilsWeinstein, John N.Weisenberger, Daniel J.Wilkerson, Matthew D.Wise, LisaWitte, JohnWu, Chia-ChinWu, JunyuanWu, YeXu, Andrew W.Yadav, Shalini S.Yang, LimingYang, LixingYau, ChristinaYe, HuihuiYena, PeggyZeng, ThomasZenklusen, Jean C.Zhang, HaileiZhang, JianhuaZhang, JiashanZhang, WeiZhong, YiZhu, KelseyZmuda, Erik
Keywords
ETS GENE FUSIONS; ACTIVE ANDROGEN RECEPTOR; DNA METHYLATION; RADICAL PROSTATECTOMY; GENOMIC ABERRATIONS; EXPRESSION PROFILES; WHOLE-GENOME; MUTATIONS; SPOP; RECURRENCE
Issue Date
2015-11
Publisher
CELL PRESS
Citation
CELL, v.163, no.4, pp.1011 - 1025
Abstract
There is substantial heterogeneity among primary prostate cancers, evident in the spectrum of molecular abnormalities and its variable clinical course. As part of The Cancer Genome Atlas (TCGA), we present a comprehensive molecular analysis of 333 primary prostate carcinomas. Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1). Epigenetic profiles showed substantial heterogeneity, including an IDH1 mutant subset with a methylator phenotype. Androgen receptor (AR) activity varied widely and in a subtype-specific manner, with SPOP and FOXA1 mutant tumors having the highest levels of AR-induced transcripts. 25% of the prostate cancers had a presumed actionable lesion in the PI3K or MAPK signaling pathways, and DNA repair genes were inactivated in 19%. Our analysis reveals molecular heterogeneity among primary prostate cancers, as well as potentially actionable molecular defects
URI
Go to Link
DOI
10.1016/j.cell.2015.10.025
ISSN
0092-8674
Appears in Collections:
SLS_Journal Papers
Files in This Item:
1-s2.0-S0092867415013392-main.pdf Download

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU