Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 1256 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 1245 | - |
dc.citation.title | CHEMICAL SCIENCE | - |
dc.citation.volume | 7 | - |
dc.contributor.author | Arambula, J. F. | - |
dc.contributor.author | McCall, R. | - |
dc.contributor.author | Sidoran, K. J. | - |
dc.contributor.author | Magda, D. | - |
dc.contributor.author | Mitchell, N. A. | - |
dc.contributor.author | Bielawski, C. W. | - |
dc.contributor.author | Lynch, V. M. | - |
dc.contributor.author | Sessler, J. L. | - |
dc.contributor.author | Arumugam, K. | - |
dc.date.accessioned | 2023-12-22T00:10:19Z | - |
dc.date.available | 2023-12-22T00:10:19Z | - |
dc.date.created | 2016-02-25 | - |
dc.date.issued | 2016-02 | - |
dc.description.abstract | Ferrocene containing N-heterocyclic carbene (NHC) ligated gold(I) complexes of the type [Au(NHC)(2)](+) were prepared and found to be capable of regulating the formation of reactive oxygen species (ROS) via multiple mechanisms. Single crystal X-ray analysis of bis(1-(ferrocenylmethyl)-3-mesitylimidazol-2-ylidene)-gold(I) chloride (5) and bis(1,3-di(ferrocenylmethyl)imidazol-2-ylidene)-gold(I) chloride (6) revealed a quasi-linear geometry around the gold(I) centers (i.e., the C-Au-C bond angle were measured to be similar to 177 degrees and all the Au-C-carbene bonds distances were in the range of 2.00 (7)-2.03 (1) angstrom). A series of cell studies indicated that cell proliferation inhibition and ROS generation were directly proportional to the amount of ferrocene contained within the [Au(NHC)(2)](+) complexes (IC50 of 6 < 5 < bis(1-benzyl-3-mesitylimidazol-2-ylidene)-gold(I) chloride (4)). Complexes 4-6 were also confirmed to inhibit thioredoxin reductase as inferred from lipoate reduction assays and increased chelatable intracellular zinc concentrations. RNA microarray gene expression assays revealed that 6 induces endoplasmic reticulum stress response pathways as a result of ROS increase | - |
dc.identifier.bibliographicCitation | CHEMICAL SCIENCE, v.7, no.2, pp.1245 - 1256 | - |
dc.identifier.doi | 10.1039/c5sc03519h | - |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.scopusid | 2-s2.0-84961383314 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18591 | - |
dc.identifier.url | http://pubs.rsc.org/en/Content/ArticleLanding/2016/SC/C5SC03519H#!divAbstract | - |
dc.identifier.wosid | 000368835300051 | - |
dc.language | 영어 | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Targeting antioxidant pathways with ferrocenylated N-heterocyclic carbene supported gold(I) complexes in A549 lung cancer cells | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | INDUCE OXIDATIVE STRESS | - |
dc.subject.keywordPlus | THIOREDOXIN REDUCTASE | - |
dc.subject.keywordPlus | MOTEXAFIN GADOLINIUM | - |
dc.subject.keywordPlus | ANTITUMOR-ACTIVITY | - |
dc.subject.keywordPlus | ANTIPROLIFERATIVE ACTIVITY | - |
dc.subject.keywordPlus | FERROCENIUM DERIVATIVES | - |
dc.subject.keywordPlus | PALLADIUM COMPLEXES | - |
dc.subject.keywordPlus | IONIZING-RADIATION | - |
dc.subject.keywordPlus | SANDWICH COMPLEXES | - |
dc.subject.keywordPlus | ANTICANCER AGENTS SYNTHESIS | - |
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