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DC Field | Value | Language |
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dc.citation.number | 11 | - |
dc.citation.startPage | e194 | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 47 | - |
dc.contributor.author | Oh, Eunseo | - |
dc.contributor.author | Lee, Ha Young | - |
dc.contributor.author | Kim, Hak Jung | - |
dc.contributor.author | Park, Yoo Jung | - |
dc.contributor.author | Seo, Jeong Kon | - |
dc.contributor.author | Park, Joon Seong | - |
dc.contributor.author | Bae, Yoe-Sik | - |
dc.date.accessioned | 2023-12-22T00:37:04Z | - |
dc.date.available | 2023-12-22T00:37:04Z | - |
dc.date.created | 2016-01-10 | - |
dc.date.issued | 2015-11 | - |
dc.description.abstract | When mouse bone marrow-derived macrophages were stimulated with serum amyloid A (SAA), which is a major acute-phase protein, there was strong inhibition of osteoclast formation induced by the receptor activator of nuclear factor kappaB ligand. SAA not only markedly blocked the expression of several osteoclast-associated genes (TNF receptor-associated factor 6 and osteoclast-associated receptor) but also strongly induced the expression of negative regulators (MafB and interferon regulatory factor 8). Moreover, SAA decreased c-fms expression on the cell surface via shedding of the c-fms extracellular domain. SAA also restrained the fusion of osteoclast precursors by blocking intracellular ATP release. This inhibitory response of SAA is not mediated by the well-known SAA receptors (formyl peptide receptor 2, Toll-like receptor 2 (TLR2) or TLR4). These findings provide insight into a novel inhibitory role of SAA in osteoclastogenesis and suggest that SAA is an important endogenous modulator that regulates bone homeostasis. | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.47, no.11, pp.e194 | - |
dc.identifier.doi | 10.1038/emm.2015.83 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.scopusid | 2-s2.0-84975302956 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18117 | - |
dc.identifier.url | http://www.nature.com/emm/journal/v47/n11/full/emm201583a.html | - |
dc.identifier.wosid | 000368678200002 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | - |
dc.title | Serum amyloid A inhibits RANKL-induced osteoclast formation | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Medicine, Research & Experimental | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Research & Experimental Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTOR | - |
dc.subject.keywordPlus | ALPHA-CONVERTING ENZYME | - |
dc.subject.keywordPlus | C-FMS | - |
dc.subject.keywordPlus | DIFFERENTIATION FACTOR | - |
dc.subject.keywordPlus | BONE-RESORPTION | - |
dc.subject.keywordPlus | M-CSF | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CELLS | - |
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