Review of Microfluidic Approaches for Surface-enhanced Raman Scattering

Abstract

The development of lab-on-a-chip (LoC) systems has allowed for the successful combination of many detection methods with these systems. Surface-enhanced Raman spectroscopy (SERS) has the potential for use in rapid trace-level biological and environmental analysis because of its high sensitivity, rapid response, and fingerprint effect. With the development of nanotechnology, various active SERS substrates have been fabricated. By combining well-designed microchannels and SERS substrates, more effective and convenient SERS detecting systems have been realized. Furthermore, novel functions that were conventionally deemed impossible for normal SERS substrates have been achieved.