Full metadata record
DC Field | Value | Language |
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dc.citation.number | 1 | - |
dc.citation.startPage | 277 | - |
dc.citation.title | GENOME BIOLOGY | - |
dc.citation.volume | 16 | - |
dc.contributor.author | Dobrynin, Pavel | - |
dc.contributor.author | Liu, Shiping | - |
dc.contributor.author | Tamazian, Gaik | - |
dc.contributor.author | Xiong, Zijun | - |
dc.contributor.author | Yurchenko, Andrey A. | - |
dc.contributor.author | Krasheninnikova, Ksenia | - |
dc.contributor.author | Kliver, Sergey | - |
dc.contributor.author | Schmidt-Küntzel, Anne | - |
dc.contributor.author | Koepfli, Klaus-Peter | - |
dc.contributor.author | Johnson, Warren | - |
dc.contributor.author | Kuderna, Lukas F.K. | - |
dc.contributor.author | García-Pérez, Raquel | - |
dc.contributor.author | Manuel, Marc de | - |
dc.contributor.author | Godinez, Ricardo | - |
dc.contributor.author | Komissarov, Aleksey | - |
dc.contributor.author | Makunin, Alexey | - |
dc.contributor.author | Brukhin, Vladimir | - |
dc.contributor.author | Qiu, Weilin | - |
dc.contributor.author | Zhou, Long | - |
dc.contributor.author | Li, Fang | - |
dc.contributor.author | Yi, Jian | - |
dc.contributor.author | Driscoll, Carlos | - |
dc.contributor.author | Antunes, Agostinho | - |
dc.contributor.author | Oleksyk, Taras K. | - |
dc.contributor.author | Eizirik, Eduardo | - |
dc.contributor.author | Perelman, Polina | - |
dc.contributor.author | Roelke, Melody | - |
dc.contributor.author | Wildt, David | - |
dc.contributor.author | Diekhans, Mark | - |
dc.contributor.author | Marques-Bonet, Tomas | - |
dc.contributor.author | Marker, Laurie | - |
dc.contributor.author | Bhak, Jong Hwa | - |
dc.contributor.author | Wang, Jun | - |
dc.contributor.author | Zhang, Guojie | - |
dc.contributor.author | O'Brien, Stephen J. | - |
dc.date.accessioned | 2023-12-22T00:19:42Z | - |
dc.date.available | 2023-12-22T00:19:42Z | - |
dc.date.created | 2015-12-30 | - |
dc.date.issued | 2015-12 | - |
dc.description.abstract | Background: Patterns of genetic and genomic variance are informative in inferring population history for human, model species and endangered populations. Results: Here the genome sequence of wild-born African cheetahs reveals extreme genomic depletion in SNV incidence, SNV density, SNVs of coding genes, MHC class I and II genes, and mitochondrial DNA SNVs. Cheetah genomes are on average 95 % homozygous compared to the genomes of the outbred domestic cat (24.08 % homozygous), Virunga Mountain Gorilla (78.12 %), inbred Abyssinian cat (62.63 %), Tasmanian devil, domestic dog and other mammalian species. Demographic estimators impute two ancestral population bottlenecks: one >100,000 years ago coincident with cheetah migrations out of the Americas and into Eurasia and Africa, and a second 11,084-12,589 years ago in Africa coincident with late Pleistocene large mammal extinctions. MHC class I gene loss and dramatic reduction in functional diversity of MHC genes would explain why cheetahs ablate skin graft rejection among unrelated individuals. Significant excess of non-synonymous mutations in AKAP4 (p < 0.02), a gene mediating spermatozoon development, indicates cheetah fixation of five function-damaging amino acid variants distinct from AKAP4 homologues of other Felidae or mammals; AKAP4 dysfunction may cause the cheetah's extremely high (>80 %) pleiomorphic sperm. Conclusions: The study provides an unprecedented genomic perspective for the rare cheetah, with potential relevance to the species' natural history, physiological adaptations and unique reproductive disposition. |
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dc.identifier.bibliographicCitation | GENOME BIOLOGY, v.16, no.1, pp.277 | - |
dc.identifier.doi | 10.1186/s13059-015-0837-4 | - |
dc.identifier.issn | 1474-760X | - |
dc.identifier.scopusid | 2-s2.0-84949776650 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18013 | - |
dc.identifier.url | http://www.genomebiology.com/2015/16/1/277 | - |
dc.identifier.wosid | 000366105700001 | - |
dc.language | 영어 | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.title | Genomic legacy of the African cheetah, Acinonyx jubatus | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology; Genetics & Heredity | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology; Genetics & Heredity | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Conservation biology | - |
dc.subject.keywordAuthor | Genetic diversity | - |
dc.subject.keywordAuthor | Population biology | - |
dc.subject.keywordPlus | MULTIPLE SEQUENCE ALIGNMENT | - |
dc.subject.keywordPlus | PHYLOGENETIC ANALYSIS | - |
dc.subject.keywordPlus | GENETIC-VARIATION | - |
dc.subject.keywordPlus | DOMESTIC CAT | - |
dc.subject.keywordPlus | EVOLUTION | - |
dc.subject.keywordPlus | DATABASE | - |
dc.subject.keywordPlus | PROGRAM | - |
dc.subject.keywordPlus | INFERENCE | - |
dc.subject.keywordPlus | ALGORITHMS | - |
dc.subject.keywordPlus | GENERATION | - |
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