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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Accumulating insights into the role of phospholipase D2 in human diseases

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dc.contributor.author Ghim, Jaewang ko
dc.contributor.author Chelakkot, Chaithanya ko
dc.contributor.author Bae, Yoe-Sik ko
dc.contributor.author Suh, Pann-Ghill ko
dc.contributor.author Ryu, Sung Ho ko
dc.date.available 2015-12-22T06:45:07Z -
dc.date.created 2015-12-22 ko
dc.date.issued 2016-05 ko
dc.identifier.citation ADVANCES IN BIOLOGICAL REGULATION, v.61, pp.42 - 46 ko
dc.identifier.issn 2212-4934 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/18003 -
dc.description.abstract Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule phosphatidic acid (PA) by catalyzing the hydrolysis of phosphatidylcholine (PC). The molecular characteristics of PLD2, the mechanisms of regulation of its activity, its functions in the signaling pathway involving PA and binding partners, and its role in cellular physiology have been extensively studied over the past decades. Although several potential roles of PLD2 have been proposed based on the results of molecular and cell-based studies, the pathophysiological functions of PLD2 in vivo have not yet been fully investigated at the organismal level. Here, we address accumulated evidences that provide insight into the role of PLD2 in human disease. We summarize recent studies using animal models that provide direct evidence of the function of PLD2 in several pathological conditions such as vascular disease, immunological disease, and neurological disease. In light of the use of recently developed PLD2-specific inhibitors showing potential in alleviating pathological conditions, improving our understanding of the role of PLD2 in human disease would be necessary to target the regulation of PLD2 activity as a therapeutic strategy. © 2015 ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher Elsevier BV ko
dc.title Accumulating insights into the role of phospholipase D2 in human diseases ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84949647201 ko
dc.type.rims ART ko
dc.description.scopustc 0 *
dc.date.scptcdate 2015-12-22 *
dc.identifier.doi 10.1016/j.jbior.2015.11.010 ko
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S2212492615300282 ko
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