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Lim, Mi Hee
MetalloNeuroChemistry Lab (MNCL)
Research Interests
  • Neurodegenerative disease, small molecule design, network between metal, proteins, and ROS

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Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives

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dc.contributor.author Korshavn, Kyle J. ko
dc.contributor.author Jang, Milim ko
dc.contributor.author Kwak, Yeon Ju ko
dc.contributor.author Kochi, Akiko ko
dc.contributor.author Vertuani, Silvia ko
dc.contributor.author Bhunia, Anirban ko
dc.contributor.author Manfredini, Stefano ko
dc.contributor.author Ramamoorthy, Ayyalusamy ko
dc.contributor.author Lim, Mi Hee ko
dc.date.available 2015-12-22T00:08:50Z -
dc.date.created 2015-12-14 ko
dc.date.issued 2015-12 ko
dc.identifier.citation SCIENTIFIC REPORTS, v.5, pp.17842 ko
dc.identifier.issn 2045-2322 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/17989 -
dc.description.abstract Both amyloid-β (Aβ) and transition metal ions are shown to be involved in the pathogenesis of Alzheimer’s disease (AD), though the importance of their interactions remains unclear. Multifunctional molecules, which can target metal-free and metal-bound Aβ and modulate their reactivity (e.g., Aβ aggregation), have been developed as chemical tools to investigate their function in AD pathology; however, these compounds generally lack specificity or have undesirable chemical and biological properties, reducing their functionality. We have evaluated whether multiple polyphenolic glycosides and their esterified derivatives can serve as specific, multifunctional probes to better understand AD. The ability of these compounds to interact with metal ions and metal-free/-associated Aβ, and further control both metal-free and metal-induced Aβ aggregation was investigated through gel electrophoresis with Western blotting, transmission electron microscopy, UV-Vis spectroscopy, fluorescence spectroscopy, and NMR spectroscopy. We also examined the cytotoxicity of the compounds and their ability to mitigate the toxicity induced by both metal-free and metal-bound Aβ. Of the polyphenols investigated, the natural product (Verbascoside) and its esterified derivative (VPP) regulate the aggregation and cytotoxicity of metal-free and/or metal-associated Aβ to different extents. Our studies indicate Verbascoside represents a promising structure for further multifunctional tool development against both metal-free Aβ and metal-Aβ. ko
dc.description.statementofresponsibility open -
dc.language 영어 ko
dc.publisher NATURE PUBLISHING GROUP ko
dc.title Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84949579877 ko
dc.identifier.wosid 000366117500001 ko
dc.type.rims ART ko
dc.description.wostc 0 *
dc.description.scopustc 0 *
dc.identifier.doi 10.1038/srep17842 ko
dc.identifier.url http://www.nature.com/articles/srep17842 ko
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