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dc.citation.startPage 17842 -
dc.citation.title SCIENTIFIC REPORTS -
dc.citation.volume 5 -
dc.contributor.author Korshavn, Kyle J. -
dc.contributor.author Jang, Milim -
dc.contributor.author Kwak, Yeon Ju -
dc.contributor.author Kochi, Akiko -
dc.contributor.author Vertuani, Silvia -
dc.contributor.author Bhunia, Anirban -
dc.contributor.author Manfredini, Stefano -
dc.contributor.author Ramamoorthy, Ayyalusamy -
dc.contributor.author Lim, Mi Hee -
dc.date.accessioned 2023-12-22T00:20:40Z -
dc.date.available 2023-12-22T00:20:40Z -
dc.date.created 2015-12-14 -
dc.date.issued 2015-12 -
dc.description.abstract Both amyloid-β (Aβ) and transition metal ions are shown to be involved in the pathogenesis of Alzheimer’s disease (AD), though the importance of their interactions remains unclear. Multifunctional molecules, which can target metal-free and metal-bound Aβ and modulate their reactivity (e.g., Aβ aggregation), have been developed as chemical tools to investigate their function in AD pathology; however, these compounds generally lack specificity or have undesirable chemical and biological properties, reducing their functionality. We have evaluated whether multiple polyphenolic glycosides and their esterified derivatives can serve as specific, multifunctional probes to better understand AD. The ability of these compounds to interact with metal ions and metal-free/-associated Aβ, and further control both metal-free and metal-induced Aβ aggregation was investigated through gel electrophoresis with Western blotting, transmission electron microscopy, UV-Vis spectroscopy, fluorescence spectroscopy, and NMR spectroscopy. We also examined the cytotoxicity of the compounds and their ability to mitigate the toxicity induced by both metal-free and metal-bound Aβ. Of the polyphenols investigated, the natural product (Verbascoside) and its esterified derivative (VPP) regulate the aggregation and cytotoxicity of metal-free and/or metal-associated Aβ to different extents. Our studies indicate Verbascoside represents a promising structure for further multifunctional tool development against both metal-free Aβ and metal-Aβ. -
dc.identifier.bibliographicCitation SCIENTIFIC REPORTS, v.5, pp.17842 -
dc.identifier.doi 10.1038/srep17842 -
dc.identifier.issn 2045-2322 -
dc.identifier.scopusid 2-s2.0-84949579877 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/17989 -
dc.identifier.url http://www.nature.com/articles/srep17842 -
dc.identifier.wosid 000366117500001 -
dc.language 영어 -
dc.publisher NATURE PUBLISHING GROUP -
dc.title Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives -
dc.type Article -
dc.description.isOpenAccess TRUE -
dc.relation.journalWebOfScienceCategory Multidisciplinary Sciences -
dc.relation.journalResearchArea Science & Technology - Other Topics -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus ALZHEIMERS-DISEASE -
dc.subject.keywordPlus ANTIOXIDANT ACTIVITY -
dc.subject.keywordPlus BIOLOGICAL-ACTIVITY -
dc.subject.keywordPlus NMR-SPECTROSCOPY -
dc.subject.keywordPlus OXIDATIVE STRESS -
dc.subject.keywordPlus INDUCED TOXICITY -
dc.subject.keywordPlus IN-VITRO -
dc.subject.keywordPlus PEPTIDE -
dc.subject.keywordPlus INHIBITION -
dc.subject.keywordPlus RUTIN -

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