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DC Field | Value | Language |
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dc.citation.endPage | 1043 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1033 | - |
dc.citation.title | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | - |
dc.citation.volume | 35 | - |
dc.contributor.author | Suh, J. Y. | - |
dc.contributor.author | Shim, Woo H. | - |
dc.contributor.author | Cho, Gyunggoo | - |
dc.contributor.author | Fan, Xiang | - |
dc.contributor.author | Kwon, Seon J. | - |
dc.contributor.author | Kim, Jeong K. | - |
dc.contributor.author | Dai, George | - |
dc.contributor.author | Wang, Xiaoying | - |
dc.contributor.author | Kim, Young R. | - |
dc.date.accessioned | 2023-12-22T01:09:49Z | - |
dc.date.available | 2023-12-22T01:09:49Z | - |
dc.date.created | 2015-10-28 | - |
dc.date.issued | 2015-06 | - |
dc.description.abstract | Vasoreactivity to hypercapnia has been used for assessing cerebrovascular tone and control altered by ischemic stroke. Despite the high prognostic potential, traits of hypercapnia-induced hemodynamic changes have not been fully characterized in relation with baseline vascular states and brain tissue damage. To monitor cerebrovascular responses, T2- and T2*-weighted magnetic resonance imaging (MRI) images were acquired alternatively using spin- and gradient-echo echo plannar imaging (GESE EPI) sequence with 5% CO2 gas inhalation in normal (n =5) and acute stroke rats (n=10). Dynamic relative changes in cerebrovascular volume (CBV), microvascular volume (MW), and vascular size index (VSI) were assessed from regions of interest (ROIs) delineated by the percent decrease of apparent diffusion coefficient (ADC). The baseline CBV was not affected by middle cerebral artery occlusion (MCAO) whereas the baseline MW in ischemic areas was significantly lower than that in the rest of the brain and correlated with ADC. Vasoreactivity to hypercapnic challenge was considerably attenuated in the entire ipsilesional hemisphere including normal ADC regions, in which unsolicited, spreading depression-associated increases of CBV and MW were observed. The lesion-dependent inhomogeneity in baseline MW indicates the effective perfusion reserve for accurately delineating the true ischemic damage while the cascade of neuronal depolarization is probably responsible for the hemispherically lateralized changes in overall neurovascular physiology | - |
dc.identifier.bibliographicCitation | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, v.35, no.6, pp.1033 - 1043 | - |
dc.identifier.doi | 10.1038/jcbfm.2015.22 | - |
dc.identifier.issn | 0271-678X | - |
dc.identifier.scopusid | 2-s2.0-84930178291 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/17611 | - |
dc.identifier.url | http://www.nature.com/jcbfm/journal/v35/n6/full/jcbfm201522a.html | - |
dc.identifier.wosid | 000355575600018 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Reduced microvascular volume and hemispherically deficient vasoreactivity to hypercapnia in acute ischemia: MRI study using permanent middle cerebral artery occlusion rat model | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism; Hematology; Neurosciences | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism; Hematology; Neurosciences & Neurology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | acute stroke | - |
dc.subject.keywordAuthor | animal models | - |
dc.subject.keywordAuthor | cerebal hemodynamics | - |
dc.subject.keywordAuthor | MRI | - |
dc.subject.keywordAuthor | brain imaging | - |
dc.subject.keywordPlus | PERFUSION COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | ACUTE STROKE PATIENTS | - |
dc.subject.keywordPlus | CORTICAL BLOOD-FLOW | - |
dc.subject.keywordPlus | CEREBROVASCULAR REACTIVITY | - |
dc.subject.keywordPlus | SPREADING DEPRESSION | - |
dc.subject.keywordPlus | CO2 REACTIVITY | - |
dc.subject.keywordPlus | FUNCTIONAL MRI | - |
dc.subject.keywordPlus | CARBON-DIOXIDE | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | CONTRAST | - |
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