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Kim, Young R.
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Reduced microvascular volume and hemispherically deficient vasoreactivity to hypercapnia in acute ischemia: MRI study using permanent middle cerebral artery occlusion rat model

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dc.contributor.author Suh, J. Y. ko
dc.contributor.author Shim, Woo H. ko
dc.contributor.author Cho, Gyunggoo ko
dc.contributor.author Fan, Xiang ko
dc.contributor.author Kwon, Seon J. ko
dc.contributor.author Kim, Jeong K. ko
dc.contributor.author Dai, George ko
dc.contributor.author Wang, Xiaoying ko
dc.contributor.author Kim, Young R. ko
dc.date.available 2015-10-28T07:41:44Z -
dc.date.created 2015-10-28 ko
dc.date.issued 2015-06 ko
dc.identifier.citation JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, v.35, no.6, pp.1033 - 1043 ko
dc.identifier.issn 0271-678X ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/17611 -
dc.description.abstract Vasoreactivity to hypercapnia has been used for assessing cerebrovascular tone and control altered by ischemic stroke. Despite the high prognostic potential, traits of hypercapnia-induced hemodynamic changes have not been fully characterized in relation with baseline vascular states and brain tissue damage. To monitor cerebrovascular responses, T2- and T2*-weighted magnetic resonance imaging (MRI) images were acquired alternatively using spin- and gradient-echo echo plannar imaging (GESE EPI) sequence with 5% CO2 gas inhalation in normal (n =5) and acute stroke rats (n=10). Dynamic relative changes in cerebrovascular volume (CBV), microvascular volume (MW), and vascular size index (VSI) were assessed from regions of interest (ROIs) delineated by the percent decrease of apparent diffusion coefficient (ADC). The baseline CBV was not affected by middle cerebral artery occlusion (MCAO) whereas the baseline MW in ischemic areas was significantly lower than that in the rest of the brain and correlated with ADC. Vasoreactivity to hypercapnic challenge was considerably attenuated in the entire ipsilesional hemisphere including normal ADC regions, in which unsolicited, spreading depression-associated increases of CBV and MW were observed. The lesion-dependent inhomogeneity in baseline MW indicates the effective perfusion reserve for accurately delineating the true ischemic damage while the cascade of neuronal depolarization is probably responsible for the hemispherically lateralized changes in overall neurovascular physiology ko
dc.description.statementofresponsibility open -
dc.language 영어 ko
dc.publisher NATURE PUBLISHING GROUP ko
dc.title Reduced microvascular volume and hemispherically deficient vasoreactivity to hypercapnia in acute ischemia: MRI study using permanent middle cerebral artery occlusion rat model ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84930178291 ko
dc.identifier.wosid 000355575600018 ko
dc.type.rims ART ko
dc.description.wostc 0 *
dc.description.scopustc 0 *
dc.date.tcdate 2015-12-28 *
dc.date.scptcdate 2015-11-04 *
dc.identifier.doi 10.1038/jcbfm.2015.22 ko
dc.identifier.url http://www.nature.com/jcbfm/journal/v35/n6/full/jcbfm201522a.html ko
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