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DC Field | Value | Language |
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dc.citation.endPage | 1086 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1080 | - |
dc.citation.title | CELL BIOLOGY INTERNATIONAL | - |
dc.citation.volume | 39 | - |
dc.contributor.author | Park, Yo Seph | - |
dc.contributor.author | Shin, Changsik | - |
dc.contributor.author | Hwang, Han Sung | - |
dc.contributor.author | Zenke, Martin | - |
dc.contributor.author | Han, Dong Wook | - |
dc.contributor.author | Kang, Young Sun | - |
dc.contributor.author | Ko, Kisung | - |
dc.contributor.author | Do, Yoonkyung | - |
dc.contributor.author | Ko, Kinarm | - |
dc.date.accessioned | 2023-12-22T00:45:28Z | - |
dc.date.available | 2023-12-22T00:45:28Z | - |
dc.date.created | 2015-09-21 | - |
dc.date.issued | 2015-09 | - |
dc.description.abstract | Dendritic cells (DCs) are the most potent antigen-presenting cells that play a crucial role in the initiation of an immune response. As DC-based therapeutic applications is increasing, large-scale DC production is required for transplantation. Human umbilical cord blood (UCB) has been shown to contain a rare and precious population of hematopoietic stem cells (HSCs), which can give rise to DCs. The CD34 antigen has been widely used as a cell surface marker to identify HSCs. In this study, we used CD34 antibody to isolate CD34+ and CD34- cells and compared the ability to differentiate into DCs. We used a two-step method combined with the magnetic bead sorting system to isolate CD34+ and CD34- cells from human UCB. Analysis of cellular properties and functionality using a migration assay and T cell proliferation assay revealed no significant differences between CD34+ cells and CD34- cells in their ability to generate DCs. | - |
dc.identifier.bibliographicCitation | CELL BIOLOGY INTERNATIONAL, v.39, no.9, pp.1080 - 1086 | - |
dc.identifier.doi | 10.1002/cbin.10490 | - |
dc.identifier.issn | 1065-6995 | - |
dc.identifier.scopusid | 2-s2.0-84939252031 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16998 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/cbin.10490/abstract | - |
dc.identifier.wosid | 000359745400011 | - |
dc.language | 영어 | - |
dc.publisher | PORTLAND PRESS LTD | - |
dc.title | In vitro generation of functional dendritic cells differentiated from CD34 negative cells isolated from human umbilical cord blood | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | CD34 | - |
dc.subject.keywordAuthor | Dendritic cells | - |
dc.subject.keywordAuthor | Differentiation | - |
dc.subject.keywordAuthor | Hematopoietic stem cells | - |
dc.subject.keywordAuthor | Human umbilical cord blood | - |
dc.subject.keywordPlus | HEMATOPOIETIC STEM-CELLS | - |
dc.subject.keywordPlus | TRANSPLANTATION TOLERANCE | - |
dc.subject.keywordPlus | LANGERHANS CELLS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PROGENITORS | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | ANTIGEN | - |
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