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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Noncovalent Surface Locking of Mesoporous Silica Nanoparticles for Exceptionally High Hydrophobic Drug Loading and Enhanced Colloidal Stability

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dc.contributor.author Palanikumar, L. ko
dc.contributor.author Kim, Ho Young ko
dc.contributor.author Oh, Joon Young ko
dc.contributor.author Thoma, Ajesh P. ko
dc.contributor.author Choi, Eun Seong ko
dc.contributor.author Jeena, M. T. ko
dc.contributor.author Joo, Sang Hoon ko
dc.contributor.author Ryu, Ja-Hyoung ko
dc.date.available 2015-09-16T02:57:21Z -
dc.date.created 2015-08-17 ko
dc.date.issued 2015-09 ko
dc.identifier.citation BIOMACROMOLECULES, v.16, no.9, pp.2701 - 2714 ko
dc.identifier.issn 1525-7797 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/16863 -
dc.description.abstract Advances in water-insoluble drug delivery systems are limited by selective delivery, loading capacity, and colloidal and encapsulation stability. We have developed a simple and robust hydrophobic-drug delivery platform with different types of hydrophobic chemotherapeutic agents using a noncovalent gatekeeper’s technique with mesoporous silica nanoparticles (MSNs). The unmodified pores offer a large volume of drug loading capacity, and the loaded drug is stably encapsulated until it enters the cancer cells owing to the noncovalently bound polymer gatekeeper. In the presence of polymer gatekeepers, the drug-loaded mesoporous silica nanoparticles showed enhanced colloidal stability. The simplicity of drug encapsulation allows any combination of small chemotherapeutics to be coencapsulated and thus produce synergetic therapeutic effects. The disulfide moiety facilitates decoration of the nanoparticles with cysteine containing ligands through thiol-disulfide chemistry under mild conditions. To show the versatility of drug targeting to cancer cells, we decorated the surface of the shell-cross-linked nanoparticles with two types of peptide ligands, SP94 and RGD. The nanocarriers reported here can release encapsulated drugs inside the reducing microenvironment of cancer cells via degradation of the polymer shell, leading to cell death. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher AMER CHEMICAL SOC ko
dc.title Noncovalent Surface Locking of Mesoporous Silica Nanoparticles for Exceptionally High Hydrophobic Drug Loading and Enhanced Colloidal Stability ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84941621479 ko
dc.identifier.wosid 000361341700016 ko
dc.type.rims ART ko
dc.description.wostc 0 *
dc.description.scopustc 0 *
dc.date.tcdate 2016-01-15 *
dc.identifier.doi 10.1021/acs.biomac.5b00589 ko
dc.identifier.url http://pubs.acs.org/doi/10.1021/acs.biomac.5b00589 ko
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