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DC Field | Value | Language |
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dc.citation.endPage | 2183 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | 2177 | - |
dc.citation.title | CURRENT BIOLOGY | - |
dc.citation.volume | 25 | - |
dc.contributor.author | Turk, Erin | - |
dc.contributor.author | Wills, Airon A | - |
dc.contributor.author | Kwon, Taejoon | - |
dc.contributor.author | Sedzinski, Jakub | - |
dc.contributor.author | Wallingford, John B | - |
dc.contributor.author | Stearns, Tim | - |
dc.date.accessioned | 2023-12-22T01:06:26Z | - |
dc.date.available | 2023-12-22T01:06:26Z | - |
dc.date.created | 2015-09-05 | - |
dc.date.issued | 2015-08 | - |
dc.description.abstract | There are six members of the tubulin superfamily in eukaryotes [1]. Alpha- and beta-tubulin form a heterodimer that polymerizes to form microtubules, and gamma-tubulin nucleates microtubules as a component of the gamma-tubulin ring complex. Alpha-, beta-, and gamma-tubulin are conserved in all eukaryotes. In contrast, delta- and epsilon-tubulin are conserved in many, but not all, eukaryotes and are associated with centrioles, although their molecular function is unclear [2-7]. Zeta-tubulin is the sixth and final member of the tubulin superfamily and is largely uncharacterized. We find that zeta-, epsilon-, and delta-tubulin form an evolutionarily co-conserved module, the ZED module, that has been lost at several junctions in eukaryotic evolution and that zeta- and delta-tubulin are evolutionarily interchangeable. Humans lack zeta-tubulin but have delta-tubulin. In Xenopus multiciliated cells, zeta-tubulin is a component of the basal foot, a centriolar appendage that connects centrioles to the apical cytoskeleton, and co-localizes there with epsilon-tubulin. Depletion of zeta-tubulin results in disorganization of centriole distribution and polarity in multiciliated cells. In contrast with multiciliated cells, zeta-tubulin in cycling cells does not localize to centrioles and is associated with the TRiC/CCT cytoplasmic chaperone complex. We conclude that zeta-tubulin facilitates interactions between the centrioles and the apical cytoskeleton as a component of the basal foot in differentiated cells and propose that the ZED tubulins are important for centriole functionalization and orientation of centrioles with respect to cellular polarity axes. | - |
dc.identifier.bibliographicCitation | CURRENT BIOLOGY, v.25, no.16, pp.2177 - 2183 | - |
dc.identifier.doi | 10.1016/j.cub.2015.06.063 | - |
dc.identifier.issn | 0960-9822 | - |
dc.identifier.scopusid | 2-s2.0-84939572971 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16824 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0960982215007903 | - |
dc.identifier.wosid | 000359882200031 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Zeta-Tubulin Is a Member of a Conserved Tubulin Module and Is a Component of the Centriolar Basal Foot in Multiciliated Cells | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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