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DC Field | Value | Language |
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dc.citation.endPage | 1068 | - |
dc.citation.startPage | 1063 | - |
dc.citation.title | PLACENTA | - |
dc.citation.volume | 36 | - |
dc.contributor.author | Yang, Yong Ryoul | - |
dc.contributor.author | Jang, Hyun-Jun | - |
dc.contributor.author | Lee, Yong Hwa | - |
dc.contributor.author | Kim, Il Shin | - |
dc.contributor.author | Lee, Ho | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T00:40:55Z | - |
dc.date.available | 2023-12-22T00:40:55Z | - |
dc.date.created | 2015-09-11 | - |
dc.date.issued | 2015-10 | - |
dc.description.abstract | Introduction: Placental vasculogenesis is essential for fetal growth and development, and is affected profoundly by oxygen tension (hypoxia). Hypoxia-inducible factor-1 alpha: (HIF-1 alpha), which is stabilized at the protein level in response to hypoxia, is essential for vascular morphogenesis in the placenta. Many studies suggested that responses to hypoxia is influenced by O-GlcNAcylation. O-GlcNAcylation is regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) that catalyze the addition and removal of O-GlcNAc respectively. Methods: We generated OGA deficient mice and evaluated OGA(-/-) placentas. The analysis of OGA(-/-) placentas was focused on morphological change and placental vasculogenesis. HIF-1 alpha: protein stability or transcriptional activity under dysregulation of O-GlcNAcylation were evaluated by Western blot, RT-qPCR and luciferase reporter gene assays in MEFs or MS1 cell line. Results: Deletion of OGA results in defective placental vasculogenesis. OGA(-/-) placentas showed an abnormal placental shape and reduced vasculature in the labyrinth, which caused a developmental delay in the embryos. OGA deletion, which elevates O-GlcNAcylation and downregulates O-GlcNAc transferase (OGT), suppressed HIF-1 alpha stabilization and the transcription of its target genes. In contrast, the overexpression of O-GlcNAc cycling enzymes enhanced the expression and transcriptional activity of HIF-1 alpha. Discussion: These results suggest that OGA plays a critical role in placental vasculogenesis by modulating HIP-1 alpha stabilization. Control of O-GlcNAcylation is essential for placental development. (C) 2015 Elsevier Ltd. All rights reserved. |
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dc.identifier.bibliographicCitation | PLACENTA, v.36, pp.1063 - 1068 | - |
dc.identifier.doi | 10.1016/j.placenta.2015.08.001 | - |
dc.identifier.issn | 0143-4004 | - |
dc.identifier.scopusid | 2-s2.0-84944280656 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16802 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S014340041530028X | - |
dc.identifier.wosid | 000364267200001 | - |
dc.language | 영어 | - |
dc.publisher | W B SAUNDERS CO LTD | - |
dc.title | O-GlcNAc cycling enzymes control vascular development of the placenta by modulating the levels of HIF-1α | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Developmental Biology; Obstetrics & Gynecology; Reproductive Biology | - |
dc.relation.journalResearchArea | Developmental Biology; Obstetrics & Gynecology; Reproductive Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | O-GlcNAcylation | - |
dc.subject.keywordAuthor | OGA | - |
dc.subject.keywordAuthor | OGT | - |
dc.subject.keywordAuthor | Placenta | - |
dc.subject.keywordAuthor | Vasculogenesis | - |
dc.subject.keywordAuthor | HIF-1 alpha | - |
dc.subject.keywordAuthor | Hypoxia | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | GLCNACYLATION | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | TRANSFERASE | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | PATHWAY | - |
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