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Seo, Young Kyo
School of Life Sciences
Research Interests
  • How the fundamental processes of gene regulation are used in the control and management of metabolic homeostasis

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Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin

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Title
Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin
Author
Kim, Kwang-YounKim, Sang-HunYu, Sun-NyoungPark, Suel-KiChoi, Hyeun-DeokYu, Hak-SunJi, Jae-HoonSeo, Young-KyoAhn, Soon-Cheol
Issue Date
2015-08
Publisher
SPANDIDOS PUBL LTD
Citation
MOLECULAR MEDICINE REPORTS, v.12, no.2, pp.1898 - 1904
Abstract
Salinomycin is a monocarboxylic polyether antibiotic, which is widely used as an anticoccidial agent. The anticancer property of salinomycin has been recognized and is based on its ability to induce apoptosis in human multidrug resistance (MDR). The present study investigated whether salinomycin reverses MDR towards chemotherapeutic agents in doxorubicin-resistant MCF-7/MDR human breast cancer cells. The results demonstrated that doxorubicin-mediated cytotoxicity was significantly enhanced by salinomycin in the MCF-7/MDR cells, and this occurred in a dose-dependent manner. This finding was consistent with subsequent observations made under a confocal microscope, in which the doxorubicin fluorescence signals of the salinomycin-treated cells were higher compared with the cells treated with doxorubicin alone. In addition, flow cytometric analysis revealed that salinomycin significantly increased the net cellular uptake and decreased the efflux of doxorubicin. The expression levels of MDR-1 and MRP-1 were not altered at either the mRNA or protein levels in the cells treated with salinomycin. These results indicated that salinomycin was mediated by its ability to increase the uptake and decrease the efflux of doxorubicin in MCF-7/MDR cells. Salinomycin reversed the resistance of doxorubicin, suggesting that chemotherapy in combination with salinomycin may benefit MDR cancer therapy
URI
https://scholarworks.unist.ac.kr/handle/201301/16559
URL
http://www.spandidos-publications.com/10.3892/mmr.2015.3633
DOI
10.3892/mmr.2015.3633
ISSN
1791-2997
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