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Suh, Pann-Ghill
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dc.citation.endPage 132 -
dc.citation.number 2 -
dc.citation.startPage 130 -
dc.citation.title NEUROSCIENCE LETTERS -
dc.citation.volume 294 -
dc.contributor.author Lee, Sang Do -
dc.contributor.author Lee, Byoung Dae -
dc.contributor.author Kim, Yong -
dc.contributor.author Suh, Pann-Ghill -
dc.contributor.author Ryu, Sung Ho -
dc.date.accessioned 2023-12-22T12:06:31Z -
dc.date.available 2023-12-22T12:06:31Z -
dc.date.created 2015-08-17 -
dc.date.issued 2000-11 -
dc.description.abstract Bradykinin (BK) activates phospholipase D (PLD) and induces several responses such as catecholamine secretion, collapse of growth cones, and gene expression in PC12 pheochromocytoma cells. Although two distinct PLD isozymes, PLD1 and PLD2, have been cloned from mammalian cells, the regulatory mechanism for each PLD isozyme by BK is not clear, In our present study, we investigated the activation mechanism of PLD2 by BK in PLD2-overexpressing PC12 cells. BK stimulated PLD2 activity in a concentration-dependent manner within 1 min and this activation was inhibited by pretreatment of the cells with protein kinase C (PKC) inhibitor. PKC alpha and PKC delta translocated from cytosol to membrane upon BK treatment, and rottlerin potently inhibited the activation of PLD2 by BK. These results suggest that BK activates PLD2 via PKC delta in PC12 cells. (C) 2000 Published by Elsevier Science Ireland Ltd -
dc.identifier.bibliographicCitation NEUROSCIENCE LETTERS, v.294, no.2, pp.130 - 132 -
dc.identifier.doi 10.1016/S0304-3940(00)01563-9 -
dc.identifier.issn 0304-3940 -
dc.identifier.scopusid 2-s2.0-0034681061 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/16525 -
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0304394000015639 -
dc.identifier.wosid 000165263200016 -
dc.language 영어 -
dc.publisher ELSEVIER IRELAND LTD -
dc.title Bradykinin activates phospholipase D2 via protein kinase C delta in PC12 cells -
dc.type Article -
dc.description.journalRegisteredClass scopus -

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