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DC Field | Value | Language |
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dc.citation.endPage | 5423 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 5419 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 85 | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Moon, Kyung Ho | - |
dc.contributor.author | Suh, Hae Won | - |
dc.contributor.author | Rhee, Sue Goo | - |
dc.date.accessioned | 2023-12-22T13:10:44Z | - |
dc.date.available | 2023-12-22T13:10:44Z | - |
dc.date.created | 2015-08-18 | - |
dc.date.issued | 1988-08 | - |
dc.description.abstract | Antibodies against an inositol phospholipid-specific phospholipase C purified from bovine brain were used to screen rat brain λgt11 expression cDNA libraries. Complete sequences of three cDNA inserts yielded a cumulative sequence of 5106 base pairs. The deduced protein had 1289 amino acids with a calculated molecular weight of 148,431. The determination of an open reading frame was aided by the amino acid sequences of 21 tryptic peptides isolated from bovine brain phospholipase C. Only 9 residues of a total of 140 amino acid residues determined for the bovine enzyme were different from those deduced from the rat cDNA. Two regions of phospholipase C (amino acid residues 555-598 and 668-705) exhibited significant amino acid similarities to the products of various tyrosine kinase-related oncogenes (yes, src, fgr, abl, fps, fes, and tck). The homologous domain was located in the region that is not essential for the protein-tyrosine kinase activity but is likely to be involved in an interaction with cellular components that modulate kinase function. Therefore, this unexpected similarity raises the possibility that the 148-kDa phospholipase C and cytoplasmic tyrosine kinases are modulated by common cellular component(s). | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.85, no.15, pp.5419 - 5423 | - |
dc.identifier.doi | 10.1073/pnas.85.15.5419 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.scopusid | 2-s2.0-0023766177 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16510 | - |
dc.identifier.url | http://www.pnas.org/content/85/15/5419 | - |
dc.identifier.wosid | A1988P574600017 | - |
dc.language | 영어 | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | INOSITOL PHOSPHOLIPID-SPECIFIC PHOSPHOLIPASE-C - COMPLETE CDNA AND PROTEIN SEQUENCES AND SEQUENCE HOMOLOGY TO TYROSINE KINASE-RELATED ONCOGENE PRODUCTS | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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