There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1122 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1109 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 57 | - |
dc.contributor.author | Meisenhelder, Jill | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Rhee, Sue Goo | - |
dc.contributor.author | Hunter, Tony | - |
dc.date.accessioned | 2023-12-22T13:10:00Z | - |
dc.date.available | 2023-12-22T13:10:00Z | - |
dc.date.created | 2015-08-19 | - |
dc.date.issued | 1989-06 | - |
dc.description.abstract | Phospholipase C-γ (PLC-γ) was rapidly phosphorylated on tyrosines and serines following PDGF and EGF treatment of quiescent 3T3 mouse fibroblasts and A431 human epidermoid cells, respectively. PDGF treatment increased PLC-γ phosphorylation within 30 sec. This lasted for up to 1 hr, and occurred at high stoichiometry. Continuous receptor occupancy was required to maintain this phosphorylation. Three major sites of tyrosine phosphorylation were detected in PLC-γ, two of which were phosphorylated in EGF-treated A431 cells. Under certain conditions PDGF receptor coimmunoprecipitated with PLC-γ, suggesting that PDGF receptor can phosphorylate PLC-γ directly. Indeed, purified PDGF or EGF receptor phosphorylated purified PLC-γ on tyrosines identical to those phosphorylated in vivo. Tyrosine phosphorylation of PLC-γ was not induced by bombesin, TPA, or insulin. Stimulation of PLC-γ tyrosine phosphorylation and the reported ability of PDGF and EGF to induce phosphatidylinositol turnover in different cells were strongly correlated. We propose that tyrosine phosphorylation of PLC-γ by PDGF and EGF receptors leads to its activation, and a consequent increase in phosphatidylinositol turnover. © 1989. | - |
dc.identifier.bibliographicCitation | CELL, v.57, no.7, pp.1109 - 1122 | - |
dc.identifier.doi | 10.1016/0092-8674(89)90048-2 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.scopusid | 2-s2.0-0024380391 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16504 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/0092867489900482 | - |
dc.identifier.wosid | A1989AE60100007 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | PHOSPHOLIPASE-C-GAMMA IS A SUBSTRATE FOR THE PDGF AND EGF RECEPTOR PROTEIN-TYROSINE KINASES INVIVO AND INVITRO | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.