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DC Field | Value | Language |
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dc.citation.endPage | 12473 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 12467 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 280 | - |
dc.contributor.author | Hwang, Jong-Ik | - |
dc.contributor.author | Kim, Hyeon Soo | - |
dc.contributor.author | Lee, Jae Ran | - |
dc.contributor.author | Kim, Eunjoon | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T10:37:01Z | - |
dc.date.available | 2023-12-22T10:37:01Z | - |
dc.date.created | 2015-08-18 | - |
dc.date.issued | 2005-04 | - |
dc.description.abstract | Phospholipase C-beta isozymes that are activated by G protein-coupled receptors ( GPCR) and heterotrimeric G proteins carry a PSD-95/Dlg/ZO-1 (PDZ) domain binding motif at their C terminus. Through interactions with PDZ domains, this motif may endow the PLC-beta isozyme with specific roles in GPCR signaling events that occur in compartmentalized regions of the plasma membrane. In this study, we identified the interaction of PLC-beta 3 with Shank2, a PDZ domain-containing multimodular scaffold in the postsynaptic density (PSD). The C terminus of PLC-beta 3, but not other PLC-beta isotypes, specifically interacts with the PDZ domain of Shank2. Homer 1b, a Shank-interacting protein that is linked to group I metabotropic glutamate receptors and IP3 receptors, forms a multiple complex with Shank2 and PLC-beta 3. Importantly, microinjection of a synthetic peptide specifically mimicking the C terminus of PLC-beta 3 markedly reduces the mGluR-mediated intracellular calcium response. These results demonstrate that Shank2 brings PLC-beta 3 closer to Homer 1b and constitutes an efficient mGluR-coupled signaling pathway in the PSD region of neuronal synapses | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.280, no.13, pp.12467 - 12473 | - |
dc.identifier.doi | 10.1074/jbc.M410740200 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.scopusid | 2-s2.0-16844362568 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16466 | - |
dc.identifier.url | http://www.jbc.org/content/280/13/12467.long | - |
dc.identifier.wosid | 000227922000050 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | The interaction of phospholipase C-beta 3 with Shank2 regulates mGluR-mediated calcium signal | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject.keywordPlus | POSTSYNAPTIC DENSITY | - |
dc.subject.keywordPlus | SYNAPTIC PROTEINS | - |
dc.subject.keywordPlus | INTRAMOLECULAR INTERACTION | - |
dc.subject.keywordPlus | PDZ DOMAINS | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | HOMER | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | COMPLEXES | - |
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