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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 637 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 631 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 9 | - |
dc.contributor.author | Kim, Myung Jong | - |
dc.contributor.author | Si, Fuchum | - |
dc.contributor.author | Kim, Su-Jeong | - |
dc.contributor.author | Hong, Seung-Bum | - |
dc.contributor.author | Hwang, Jong-Ik | - |
dc.contributor.author | Lee, He-Jin | - |
dc.contributor.author | Lee, Seung-Jae | - |
dc.contributor.author | Chang, Jong-Soo | - |
dc.contributor.author | Lee, Young Han | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T12:09:19Z | - |
dc.date.available | 2023-12-22T12:09:19Z | - |
dc.date.created | 2015-08-20 | - |
dc.date.issued | 1999-12 | - |
dc.description.abstract | Phospholipase C-gamma 1 (PLC-gamma 1) is a lipase that hydrolyzes PIP2 to generate two second messengers, IP3 and DAG, By using the yeast two-hybrid system, we identified the translational elongation factor-1 alpha (EF-1 alpha) as a binding protein of PLC-gamma 1 from the human B-lymphocyte library, Direct interaction between EF-1 alpha and PLC-gamma 1 was confirmed by the in vitro binding experiment using purified PLC-gamma 1, Furthermore, from the in vitro binding experiment, we could demonstrate that the carboxyl terminal region of EF-1 alpha is involved in the interaction with PLC-gamma 1, and that both SH2 and SH3 domains of PLC-gamma 1 are required for the interaction with EF-1 alpha. In vivo interaction between EF-1 alpha and PLC-gamma 1 was confirmed by the immunoprecipitation experiment using anti-EF-1 alpha antibody. The interaction between EF-1 alpha and PLC-gamma 1 was enhanced by EGF-treatment, Taken together, we suggest that EF-1 alpha might play a role in PLC-gamma 1-mediated signal transduction | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.9, no.6, pp.631 - 637 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.scopusid | 2-s2.0-0033621283 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16454 | - |
dc.identifier.url | http://www.molcells.org/journal/view.html?year=1999&volume=9&number=6&spage=631 | - |
dc.identifier.wosid | 000084460500009 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | The SH2-SH2-SH3 domain of phospholipase C-gamma 1 directly binds to translational elongation factor-1 alpha | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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