File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

서판길

Suh, Pann-Ghill
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Full metadata record

DC Field Value Language
dc.citation.endPage 262 -
dc.citation.number 4 -
dc.citation.startPage 257 -
dc.citation.title EXPERIMENTAL AND MOLECULAR MEDICINE -
dc.citation.volume 33 -
dc.contributor.author Kim, Youndong -
dc.contributor.author Bae, Yeo-Sik -
dc.contributor.author Park, Jun Chul -
dc.contributor.author Suh, Pann-Ghill -
dc.contributor.author Ryu, Sung Ho -
dc.date.accessioned 2023-12-22T11:41:03Z -
dc.date.available 2023-12-22T11:41:03Z -
dc.date.created 2015-08-21 -
dc.date.issued 2001-12 -
dc.description.abstract His-Phe-Tyr-Leu-Pro-Met (HFYLPM) is a synthetic peptide that stimulates Jurkat T cells resulting in intracellular calcium ([Ca2+](i)) increase in a pertussis toxin (PTX)-sensitive manner. We have examined the physiological role of the peptide in T cell activity by comparative investigation of intracellular signaling pathways accompanied with HFYLPM-induced T cell chemotaxis with a well-known chemokine, stromal cell-derived factor-1 (SDF-1)-induced signalings. Wortmannin and genistein inhibited both of HFYLPM- and SDF-1-induced Jurkat T cell chemotaxis indicating that phosphoinositide-3-kinase and tyrosine kinase activity were required for the processes. However, U-73122 and BAPTA/AM preferentially blocked HFYLPM- but not SDF-1-induced T cell chemotaxis. It indicates that phospholipase C/calcium signaling is necessary for only chemotaxis by HFYLPM. One of the well-known cellular molecules involving chemotaxis, extracellular signal-regulated protein kinase (ERK), was activated by SDF-1 but not by HFYLPM ruling out a possible role of ERK on the peptide-mediated chemotaxis. These results indicate that the synthetic peptide, HFYLPM, stimulates T cell chemotaxis showing unique signaling and provide a useful tool for the study of T cell activation mechanism -
dc.identifier.bibliographicCitation EXPERIMENTAL AND MOLECULAR MEDICINE, v.33, no.4, pp.257 - 262 -
dc.identifier.issn 1226-3613 -
dc.identifier.scopusid 2-s2.0-0035980909 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/16449 -
dc.identifier.url http://www.nature.com/emm/journal/v33/n4/abs/emm200142a.html -
dc.identifier.wosid 000173163600012 -
dc.language 영어 -
dc.publisher KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY -
dc.title The synthetic peptide, His-Phe-Tyr-Leu-Pro-Met, is a chemoattractant for Jukat T cells -
dc.type Article -
dc.description.journalRegisteredClass scopus -

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.