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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 262 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 257 | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 33 | - |
dc.contributor.author | Kim, Youndong | - |
dc.contributor.author | Bae, Yeo-Sik | - |
dc.contributor.author | Park, Jun Chul | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.date.accessioned | 2023-12-22T11:41:03Z | - |
dc.date.available | 2023-12-22T11:41:03Z | - |
dc.date.created | 2015-08-21 | - |
dc.date.issued | 2001-12 | - |
dc.description.abstract | His-Phe-Tyr-Leu-Pro-Met (HFYLPM) is a synthetic peptide that stimulates Jurkat T cells resulting in intracellular calcium ([Ca2+](i)) increase in a pertussis toxin (PTX)-sensitive manner. We have examined the physiological role of the peptide in T cell activity by comparative investigation of intracellular signaling pathways accompanied with HFYLPM-induced T cell chemotaxis with a well-known chemokine, stromal cell-derived factor-1 (SDF-1)-induced signalings. Wortmannin and genistein inhibited both of HFYLPM- and SDF-1-induced Jurkat T cell chemotaxis indicating that phosphoinositide-3-kinase and tyrosine kinase activity were required for the processes. However, U-73122 and BAPTA/AM preferentially blocked HFYLPM- but not SDF-1-induced T cell chemotaxis. It indicates that phospholipase C/calcium signaling is necessary for only chemotaxis by HFYLPM. One of the well-known cellular molecules involving chemotaxis, extracellular signal-regulated protein kinase (ERK), was activated by SDF-1 but not by HFYLPM ruling out a possible role of ERK on the peptide-mediated chemotaxis. These results indicate that the synthetic peptide, HFYLPM, stimulates T cell chemotaxis showing unique signaling and provide a useful tool for the study of T cell activation mechanism | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.33, no.4, pp.257 - 262 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.scopusid | 2-s2.0-0035980909 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16449 | - |
dc.identifier.url | http://www.nature.com/emm/journal/v33/n4/abs/emm200142a.html | - |
dc.identifier.wosid | 000173163600012 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | - |
dc.title | The synthetic peptide, His-Phe-Tyr-Leu-Pro-Met, is a chemoattractant for Jukat T cells | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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