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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 338 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 329 | - |
dc.citation.title | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.volume | 71 | - |
dc.contributor.author | Bae, Yoe-Sik | - |
dc.contributor.author | Kim, Youndong | - |
dc.contributor.author | Park, Jun Chul | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.date.accessioned | 2023-12-22T11:39:37Z | - |
dc.date.available | 2023-12-22T11:39:37Z | - |
dc.date.created | 2015-08-21 | - |
dc.date.issued | 2002-02 | - |
dc.description.abstract | Previously, we showed that Trp-Lys-Tyr-Met-Val-D-Met (WKYMVm) stimulates superoxide generation and chemotactic migration in monocytes and neutrophils. In this study, we examined the effect of WKYMVm on monocyte survival. Serum starvation-induced monocyte death was attenuated in the presence of WKYMVm, which was abated when the cells were preincubated with LY294002, suggesting the involvement of phosphoinositide-3-kinase (PI 3-kinase) in the peptide-induced monocyte survival. WKYMVm stimulated ERK and Akt activity via PI 3-kinase activation in monocytes. We also investigated the signaling pathway of WKYMVm-induced ERK and Akt activation. The WKYMVm-induced ERK activation was PI 3-kinase-dependent but PKC-independent. However, Akt activation by WKYMVm was dependent not only on PI 3-kinase but also on the PKC pathway. When monocytes were incubated with WKYMVm, caspase-3 activity, which is important for cell death, was inhibited. Pretreatment of the cells with LY294002, GF109203X, and Go 6976 but not PD98059 blocked WKYMVm-induced monocyte survival and caspase-3 inhibition. In summary, the novel chemoattractant WKYMVm enhances monocyte survival via Akt-mediated pathways, and in this process, PKC and PI 3-kinase act upstream of Akt | - |
dc.identifier.bibliographicCitation | JOURNAL OF LEUKOCYTE BIOLOGY, v.71, no.2, pp.329 - 338 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.scopusid | 2-s2.0-0036486776 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16448 | - |
dc.identifier.url | http://www.jleukbio.org/content/71/2/329.long | - |
dc.identifier.wosid | 000173810900019 | - |
dc.language | 영어 | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.title | The synthetic chemoattractant peptide, Trp-Lys-Tyr-Met-Val-D-Met, enhances monocyte survival via PKC-dependent Akt activation | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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