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Kee, Jung-Min
Bioorganic and Chembio Lab
Research Interests
  • Chemical biology, organic synthesis, peptide chemistry, synthetic protein chemistry

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Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities

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dc.contributor.author Wender, Paul A. ko
dc.contributor.author Buschmann, Nicole ko
dc.contributor.author Cardin, Nate B. ko
dc.contributor.author Jones, Lisa R. ko
dc.contributor.author Kan, Cindy ko
dc.contributor.author Kee, Jung-Min ko
dc.contributor.author Kowalski, John A. ko
dc.contributor.author Longcore, Kate E. ko
dc.date.available 2015-08-10T07:47:45Z -
dc.date.created 2015-07-29 ko
dc.date.issued 2011-08 ko
dc.identifier.citation NATURE CHEMISTRY, v.3, no.8, pp.615 - 618 ko
dc.identifier.issn 1755-4330 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/13399 -
dc.description.abstract The daphnane diterpene orthoesters constitute a structurally fascinating family of natural products that exhibit a remarkable range of potent biological activities. Although partial activity information is available for some natural daphnanes, little information exists for non-natural congeners or on how changes in structure affect mode of action, function, potency or selectivity. A gateway strategy designed to provide general synthetic access to natural and non-natural daphnanes is described and utilized in the synthesis of two novel members of this class. In this study, a commercially available tartrate derivative was elaborated through a key late-stage diversification intermediate into B-ring yuanhuapin analogues to initiate exploration of the structure-function relationships of this class. Protein kinase C was identified as a cellular target for these agents, and their activity against human lung and leukaemia cell lines was evaluated. The natural product and a novel non-natural analogue exhibited significant potency, but the epimeric epoxide was essentially inactive. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher NATURE PUBLISHING GROUP ko
dc.title Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-79960664964 ko
dc.identifier.wosid 000292999100014 ko
dc.type.rims ART ko
dc.description.wostc 15 *
dc.description.scopustc 15 *
dc.date.tcdate 2015-12-28 *
dc.date.scptcdate 2015-11-04 *
dc.identifier.doi 10.1038/nchem.1074 ko
dc.identifier.url http://www.nature.com/nchem/journal/v3/n8/full/nchem.1074.html ko
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