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Kee, Jung-Min
Bioorganic and Chembio Lab
Research Interests
  • Chemical biology, organic synthesis, peptide chemistry, synthetic protein chemistry


Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities

DC Field Value Language Wender, Paul A. ko Buschmann, Nicole ko Cardin, Nate B. ko Jones, Lisa R. ko Kan, Cindy ko Kee, Jung-Min ko Kowalski, John A. ko Longcore, Kate E. ko 2015-08-10T07:47:45Z - 2015-07-29 ko 2011-08 ko
dc.identifier.citation NATURE CHEMISTRY, v.3, no.8, pp.615 - 618 ko
dc.identifier.issn 1755-4330 ko
dc.identifier.uri -
dc.description.abstract The daphnane diterpene orthoesters constitute a structurally fascinating family of natural products that exhibit a remarkable range of potent biological activities. Although partial activity information is available for some natural daphnanes, little information exists for non-natural congeners or on how changes in structure affect mode of action, function, potency or selectivity. A gateway strategy designed to provide general synthetic access to natural and non-natural daphnanes is described and utilized in the synthesis of two novel members of this class. In this study, a commercially available tartrate derivative was elaborated through a key late-stage diversification intermediate into B-ring yuanhuapin analogues to initiate exploration of the structure-function relationships of this class. Protein kinase C was identified as a cellular target for these agents, and their activity against human lung and leukaemia cell lines was evaluated. The natural product and a novel non-natural analogue exhibited significant potency, but the epimeric epoxide was essentially inactive. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.title Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-79960664964 ko
dc.identifier.wosid 000292999100014 ko
dc.type.rims ART ko
dc.description.wostc 15 *
dc.description.scopustc 15 * 2015-12-28 * 2015-11-04 *
dc.identifier.doi 10.1038/nchem.1074 ko
dc.identifier.url ko
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