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Kang, Hyun-Wook
3D Biofabrication Lab (3BL)
Research Interests
  • 3D Bioprinting, tissue engineering and regenerative medicine, Body-on-a-chip

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Application of microstereolithography in the development of three-dimensional cartilage regeneration scaffolds

Cited 38 times inthomson ciCited 46 times inthomson ci
Title
Application of microstereolithography in the development of three-dimensional cartilage regeneration scaffolds
Other Titles
Application of microstereolithography in the development of three-dimensional cartilage regeneration scaffolds
Author
Lee, Seung-JaeKang, Hyun-WookPark, Jung KyuRhie, Jong-WonHahn, Sei KwangCho, Dong-Woo
Keywords
CARBONATE-BASED PREPOLYMERS; MICRO-STEREOLITHOGRAPHY; DESIGN; FABRICATION; CONSTRUCTS; TISSUES
Issue Date
2008-04
Publisher
SPRINGER
Citation
BIOMEDICAL MICRODEVICES, v.10, no.2, pp.233 - 241
Abstract
Conventional methods for fabricating three-dimensional (3-D) tissue engineering scaffolds have substantial limitations. In this paper, we present a method for applying microstereolithography in the construction of 3-D cartilage scaffolds. The system provides the ability to fabricate scaffolds having a pre-designed internal structure, such as pore size and porosity, by stacking photopolymerized materials. To control scaffold structure, CAD/CAM technology was used to generate a scaffold pattern algorithm. Since tissue scaffolds must be constructed using a biocompatible, biodegradable material, scaffolds were synthesized using liquid photocurable TMC/TMP, followed by acrylation at the terminal ends, and photocured under UV light irradiation. The solidification properties of the TMC/TMP polymer were also assessed. To assess scaffold functionality, chondrocytes were seeded on two types of 3-D scaffold and characterized for cell adhesion. Results indicate that scaffold geometry plays a critical role in chondrocyte adhesion, ultimately affecting the tissue regeneration utility of the scaffolds. These 3-D scaffolds could eventually lead to optimally designed constructs for the regeneration of various tissues, such as cartilage and bone
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DOI
10.1007/s10544-007-9129-4
ISSN
1387-2176
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BME_Journal Papers
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