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권태준

Kwon, Taejoon
TaejoonLab
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dc.citation.endPage 2380 -
dc.citation.number 5 -
dc.citation.startPage 2370 -
dc.citation.title JOURNAL OF PROTEOME RESEARCH -
dc.citation.volume 13 -
dc.contributor.author Kwon, Taejoon -
dc.contributor.author Huse, Holly K. -
dc.contributor.author Vogel, Christine -
dc.contributor.author Whiteley, Marvin -
dc.contributor.author Marcotte, Edward M. -
dc.date.accessioned 2023-12-22T02:40:26Z -
dc.date.available 2023-12-22T02:40:26Z -
dc.date.created 2015-08-04 -
dc.date.issued 2014-05 -
dc.description.abstract Recent studies have shown that the concentrations of proteins expressed from orthologous genes are often conserved across organisms and to a greater extent than the abundances of the corresponding mRNAs. However, such studies have not distinguished between evolutionary (e.g., sequence divergence) and environmental (e.g., growth condition) effects on the regulation of steady-state protein and mRNA abundances. Here, we systematically investigated the transcriptome and proteome of two closely related Pseudomonas aeruginosa strains, PAO1 and PA14, under identical experimental conditions, thus controlling for environmental effects. For 703 genes observed by both shotgun proteomics and microarray experiments, we found that the protein-to-mRNA ratios are highly correlated between orthologous genes in the two strains to an extent comparable to protein and mRNA abundances. In spite of this high molecular similarity between PAO1 and PA14, we found that several metabolic, virulence, and antibiotic resistance genes are differentially expressed between the two strains, mostly at the protein but not at the mRNA level. Our data demonstrate that the magnitude and direction of the effect of protein abundance regulation occurring after the setting of mRNA levels is conserved between bacterial strains and is important for explaining the discordance between mRNA and protein abundances -
dc.identifier.bibliographicCitation JOURNAL OF PROTEOME RESEARCH, v.13, no.5, pp.2370 - 2380 -
dc.identifier.doi 10.1021/pr4011684 -
dc.identifier.issn 1535-3893 -
dc.identifier.scopusid 2-s2.0-84899855470 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/13321 -
dc.identifier.url http://pubs.acs.org/doi/abs/10.1021/pr4011684 -
dc.identifier.wosid 000335490600013 -
dc.language 영어 -
dc.publisher AMER CHEMICAL SOC -
dc.title.alternative Protein-to-mRNA Ratios Are Conserved between Pseudomonas aeruginosa Strains -
dc.title Protein-to-mRNA Ratios Are Conserved between Pseudomonas aeruginosa Strains -
dc.type Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -

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