Related Researcher

Author's Photo

Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS


Mapping protein family interactions: Intramolecular and intermolecular protein family interaction repertoires in the PDB and yeast

DC Field Value Language Bhak, Jong Hwa ko Lappe, Michael ko Teichmann, Sarah A. ko 2015-08-03T02:25:31Z - 2015-08-03 ko 2001-03 -
dc.identifier.citation JOURNAL OF MOLECULAR BIOLOGY, v.307, no.3, pp.929 - 938 ko
dc.identifier.issn 0022-2836 ko
dc.identifier.uri -
dc.identifier.uri ko
dc.description.abstract In the postgenomic era, one of the most interesting and important challenges is to understand protein interactions on a large scale. The physical interactions between protein domains are fundamental to the workings of a cell: in multi-domain polypeptide chains, in multi-subunit proteins and in transient complexes between proteins that also exist independently. To study the large-scale patterns and evolution of interactions between protein domains, we view interactions between protein domains in terms of the interactions between structural families of evolutionarily related domains. This allows us to classify 8151 interactions betu een individual domains in the Protein Data Bank and the yeast Saccharromyces cerevisiae in terms of 664 types of interactions, between protein families. At least 51 interactions do not occur in the Protein Data Bank and can only be derived from the yeast data. The map of interactions between protein families has the form of a scale-free network, meaning that most protein families only interact with one or two other families, while a few families are extremely versatile in their interactions and are connected to many families. We observe that almost half of all known families engage in interactions with domains from their own family. We also see that the repertoires of interactions of domains within and between polypeptide chains overlap mostly for two specific types of protein families: enzymes and same-family interactions. This suggests that different types of protein interaction repertoires exist for structural, functional and regulatory reasons. (C) 2001 Academic Press ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.subject GENE FUSION ko
dc.subject SEQUENCES ko
dc.subject SUBUNIT ko
dc.subject GENOMES ko
dc.subject NETWORKS ko
dc.subject LANGUAGE ko
dc.subject DATABASE ko
dc.subject SURFACE ko
dc.subject SITES ko
dc.title Mapping protein family interactions: Intramolecular and intermolecular protein family interaction repertoires in the PDB and yeast ko
dc.title.alternative Mapping protein family interactions: intramolecular and intermolecular protein family interaction repertoires ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-0035970298 ko
dc.identifier.wosid 000167930300015 ko
dc.type.rims ART ko
dc.description.wostc 122 *
dc.description.scopustc 127 * 2015-12-28 * 2015-11-04 * 2015-11-04 *
dc.identifier.doi 10.1006/jmbi.2001.4526 ko
Appears in Collections:
BME_Journal Papers

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show simple item record


  • mendeley


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.