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Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

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MitoInteractome: Mitochondrial protein interactome database, and its application in 'aging network' analysis

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dc.contributor.author Reja, Rohit ko
dc.contributor.author Venkatakrishnan, A. J. ko
dc.contributor.author Lee, Jungwoo ko
dc.contributor.author Kim, Byoung-Chul ko
dc.contributor.author Ryu, Jea-Woon ko
dc.contributor.author Gong, Sungsam ko
dc.contributor.author Bhak, Jong Hwa ko
dc.contributor.author Park, Daeui ko
dc.date.available 2015-08-03T00:13:53Z -
dc.date.created 2015-08-03 ko
dc.date.issued 2009-09 -
dc.identifier.citation BMC GENOMICS, v.10, no.SUPPL. 3, pp.S20 - ko
dc.identifier.issn 1471-2164 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/13226 -
dc.identifier.uri http://www.biomedcentral.com/1471-2164/10/S3/S20 ko
dc.description.abstract Background: Mitochondria play a vital role in the energy production and apoptotic process of eukaryotic cells. Proteins in the mitochondria are encoded by nuclear and mitochondrial genes. Owing to a large increase in the number of identified mitochondrial protein sequences and completed mitochondrial genomes, it has become necessary to provide a web-based database of mitochondrial protein information. Results: We present 'MitoInteractome', a consolidated web-based portal containing a wealth of information on predicted protein-protein interactions, physico-chemical properties, polymorphism, and diseases related to the mitochondrial proteome. MitoInteractome contains 6,549 protein sequences which were extracted from the following databases: SwissProt, MitoP, MitoProteome, HPRD and Gene Ontology database. The first general mitochondrial interactome has been constructed based on the concept of 'homologous interaction' using PSIMAP (Protein Structural Interactome MAP) and PEIMAP (Protein Experimental Interactome MAP). Using the above mentioned methods, protein-protein interactions were predicted for 74 species. The mitochondrial protein interaction data of humans was used to construct a network for the aging process. Analysis of the 'aging network' gave us vital insights into the interactions among proteins that influence the aging process. Conclusion: MitoInteractome is a comprehensive database that would (1) aid in increasing our understanding of the molecular functions and interaction networks of mitochondrial proteins, (2) help in identifying new target proteins for experimental research using predicted protein-protein interaction information, and (3) help in identifying biomarkers for diagnosis and new molecular targets for drug development related to mitochondria. MitoInteractome is available at http://mitointeractome.kobic.kr/ ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher BIOMED CENTRAL LTD ko
dc.subject MOLECULAR INTERACTION DATABASE ko
dc.subject GENE ONTOLOGY ko
dc.subject CELL ko
dc.subject DISORDERS ko
dc.subject RESOURCE ko
dc.subject SIGNALS ko
dc.subject DAMAGE ko
dc.subject YEAST ko
dc.subject SNPS ko
dc.subject TOOL ko
dc.title MitoInteractome: Mitochondrial protein interactome database, and its application in 'aging network' analysis ko
dc.title.alternative MitoInteractome: Mitochondrial protein interactome database, and its application in 'aging network' analysis ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-71549160028 ko
dc.identifier.wosid 000272356000020 ko
dc.type.rims ART ko
dc.description.wostc 14 *
dc.description.scopustc 18 *
dc.date.tcdate 2015-12-28 *
dc.date.scptcdate 2015-11-04 *
dc.identifier.doi 10.1186/1471-2164-10-S3-S20 ko
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