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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1320 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1309 | - |
dc.citation.title | APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | - |
dc.citation.volume | 160 | - |
dc.contributor.author | Mu, Hang | - |
dc.contributor.author | Lue, Zhi-Rong | - |
dc.contributor.author | Park, Daeui | - |
dc.contributor.author | Kim, Byoung-Chul | - |
dc.contributor.author | Bhak, Jong Hwa | - |
dc.contributor.author | Zou, Fei | - |
dc.contributor.author | Yang, Jun-Mo | - |
dc.contributor.author | Li, Sen | - |
dc.contributor.author | Park, Yong-Doo | - |
dc.contributor.author | Zou, He-Chang | - |
dc.contributor.author | Zhou, Hai-Meng | - |
dc.date.accessioned | 2023-12-22T07:11:42Z | - |
dc.date.available | 2023-12-22T07:11:42Z | - |
dc.date.created | 2015-07-31 | - |
dc.date.issued | 2010-03 | - |
dc.description.abstract | We studied the effect of Zn2+ on the folding and aggregation of brain creatine kinase (CK-BB). We developed a method to purify CK-BB from rabbit brain and conducted inhibition kinetics and unfolding studies of CK-BB. Zn2+ conspicuously aggregated and osmolytes, such as glycine and proline, were able to suppress the formation of aggregates and protect the enzymatic activity against Zn2+. These results suggest that Zn2+ might act as a risk factor for CK-BB in the brain under certain conditions, and some osmolytes may help CK-BB to sustain the active state when Zn2+ is present. Our study provides useful information regarding the effect of Zn2+ on brain-derived metabolic enzymes, especially those that are putatively related to brain disease. Furthermore, our study suggests that although Zn2+ may induce CK-BB inactivation and misfolding, the ability of some abundant proteins and osmolytes to chelate Zn2+ nonspecifically may protect CK-BB and allow it to exist in the active form | - |
dc.identifier.bibliographicCitation | APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, v.160, no.5, pp.1309 - 1320 | - |
dc.identifier.doi | 10.1007/s12010-009-8574-3 | - |
dc.identifier.issn | 0273-2289 | - |
dc.identifier.scopusid | 2-s2.0-77949282194 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/13221 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs12010-009-8574-3 | - |
dc.identifier.wosid | 000274398500005 | - |
dc.language | 영어 | - |
dc.publisher | HUMANA PRESS INC | - |
dc.title.alternative | Kinetics of Zn2+ -induced Brain Type Creatine Kinase Unfolding and Aggregation. | - |
dc.title | Kinetics of Zn2+-induced Brain Type Creatine Kinase Unfolding and Aggregation | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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