dc.citation.endPage |
54 |
- |
dc.citation.number |
2 |
- |
dc.citation.startPage |
52 |
- |
dc.citation.title |
GENOMICS & INFORMATICS |
- |
dc.citation.volume |
3 |
- |
dc.contributor.author |
Bhak, Jong |
- |
dc.contributor.author |
Park, Dae-Ui |
- |
dc.contributor.author |
Lee, Jung-Sul |
- |
dc.date.accessioned |
2023-12-22T10:36:16Z |
- |
dc.date.available |
2023-12-22T10:36:16Z |
- |
dc.date.created |
2015-07-31 |
- |
dc.date.issued |
2005-06 |
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dc.description.abstract |
Motivation: Many genomes have been completely sequenced. However, detecting and analyzing their protein-protein interactions by experimental methods such as co-immunoprecipitation, tandem affinity purification and Y2H is not as fast as genome sequencing. Therefore, a computational prediction method based on the known protein structural interactions will be useful to analyze large-scale protein-protein interaction rules within and among complete genomes. Results: We confirmed that all the predicted protein family interactomes (the full set of protein family interactions within a proteome) of 146 species are scale-free networks, and they share a small core network comprising 36 protein families related to indispensable cellular functions. We found two fundamental differences among prokaryotic and eukaryotic interactomes: (1) eukarya had significantly more hub families than archaea and bacteria and (2) certain special hub families determined the topology of the eukaryotic interactomes. Our comparative analysis suggests that a very small number of expansive protein families led to the evolution of interactomes and seemed tohave played a key role in species diversification. |
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dc.identifier.bibliographicCitation |
GENOMICS & INFORMATICS, v.3, no.2, pp.52 - 54 |
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dc.identifier.issn |
1598-866X |
- |
dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/13199 |
- |
dc.identifier.url |
http://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001046125&locale=en&SID=U1lPVjGJwjRO5BJxSsx |
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dc.language |
영어 |
- |
dc.publisher |
한국유전체학회 |
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dc.title.alternative |
BioCovi: A visualization service for comparative genomics analysis |
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dc.title |
BioCovi: A Visualization Service for Comparative Genomics Analysis |
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dc.type |
Article |
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dc.description.journalRegisteredClass |
other |
- |