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DC Field | Value | Language |
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dc.citation.endPage | 667 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 662 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 377 | - |
dc.contributor.author | Yoon, Hyun Kyung | - |
dc.contributor.author | Sohn, Kyung-Cheol | - |
dc.contributor.author | Lee, Jung-Suk | - |
dc.contributor.author | Kim, Yu Jin | - |
dc.contributor.author | Bhak, Jong Hwa | - |
dc.contributor.author | Yang, Jun-Mo | - |
dc.contributor.author | You, Kwan-Hee | - |
dc.contributor.author | Kim, Chang-Deok | - |
dc.contributor.author | Lee, Jeung-Hoon | - |
dc.date.accessioned | 2023-12-22T08:13:58Z | - |
dc.date.available | 2023-12-22T08:13:58Z | - |
dc.date.created | 2015-07-31 | - |
dc.date.issued | 2008-12 | - |
dc.description.abstract | Terminal differentiation of skin keratinocytes is a vertically directed multi-step process that is tightly controlled by the sequential expression of a variety of genes. We previously investigated the gene expression profile and found that many of differentiation-related genes expressed in a temporally regulated manner. In this study, we attempted to find the hub-molecules and their intracellular signaling networks during keratinocyte differentiation using in silico analysis of data obtained from previous studies. We used protein-protein interaction prediction software called PSIMAP, and drew a hypothetical signaling network. We chose one candidate hub-molecule SHC1 that were predicted to link EGFR and MAPK signal, and then evaluated the protein-protein interactions experimentally. As predicted, SHC1 bound to the MEK1 in an EGF-regulated manner. Furthermore, SHC1 bound to the MEK1 and p38 MAPK in a keratinocyte differentiation dependent manner. These results demonstrate that in silico protein-protein interaction prediction system can be used to efficiently and cost-effectively select the experimental candidates. (C) 2008 Elsevier Inc. All rights reserved | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.377, no.2, pp.662 - 667 | - |
dc.identifier.doi | 10.1016/j.bbrc.2008.10.051 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.scopusid | 2-s2.0-55549124163 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/13187 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X0802007X | - |
dc.identifier.wosid | 000261301600064 | - |
dc.language | 영어 | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title.alternative | Prediction and evaluation of protein-protein interaction in keratinocyte differentiation. | - |
dc.title | Prediction and evaluation of protein-protein interaction in keratinocyte differentiation | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Keratinocyte | - |
dc.subject.keywordAuthor | PSIMAP | - |
dc.subject.keywordAuthor | Protein-protein interaction network | - |
dc.subject.keywordAuthor | SHC1 | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordPlus | SUPPRESSION-SUBTRACTIVE HYBRIDIZATION | - |
dc.subject.keywordPlus | CORNIFIED CELL-ENVELOPE | - |
dc.subject.keywordPlus | CALCIUM-INDUCIBLE GENES | - |
dc.subject.keywordPlus | STRUCTURAL INTERACTOME | - |
dc.subject.keywordPlus | BARRIER | - |
dc.subject.keywordPlus | PSIMAP | - |
dc.subject.keywordPlus | YEAST | - |
dc.subject.keywordPlus | MAP | - |
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