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Kwon, Taejoon
TaejoonLab
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  • Systems biology, computational biology, functional genomics

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Molecular Polymorphism and Divergence of Duplicated Genes in Tetraploid African Clawed Frogs (Xenopus)

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dc.contributor.author Evans, Ben ko
dc.contributor.author Kwon, Taejoon ko
dc.date.available 2015-07-30T00:47:56Z -
dc.date.created 2015-07-28 ko
dc.date.issued 2015-08 ko
dc.identifier.citation CYTOGENETIC AND GENOME RESEARCH, v.145, pp.243 - 252 ko
dc.identifier.issn 1424-8581 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/13041 -
dc.description.abstract Genome duplication creates redundancy in proteins and their interaction networks, and subsequent smaller-scale gene duplication can further amplify genetic redundancy. Mutations then lead to the loss, maintenance or functional divergence of duplicated genes. Genome duplication occurred many times in African clawed frogs (genus Xenopus), and almost all extant species in this group evolved from a polyploid ancestor. To better understand the nature of selective constraints in a polyploid genome, we examined molecular polymorphism and divergence of duplicates and single-copy genes in 2 tetraploid African clawed frog species, Xenopus laevis and X. victorianus. We found that molecular polymorphism in the coding regions of putative duplicated genes was higher than in singletons, but not significantly so. Our findings also suggest that transcriptome evolution in polyploids is influenced by variation in the genome-wide mutation rate, and do not reject the hypothesis that gene dosage balance is also important. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher KARGER ko
dc.title Molecular Polymorphism and Divergence of Duplicated Genes in Tetraploid African Clawed Frogs (Xenopus) ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84941941456 ko
dc.identifier.wosid 000360929900007 ko
dc.type.rims ART ko
dc.description.wostc 0 *
dc.description.scopustc 0 *
dc.date.tcdate 2015-12-28 *
dc.date.scptcdate 2015-11-04 *
dc.identifier.doi 10.1159/000431108 ko
dc.identifier.url http://www.karger.com/Article/FullText/431108 ko
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